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A point mutation in the Pdia6 gene results in loss of pancreatic ß-cell identity causing overt diabetes.
Chhabra, Nirav Florian; Amend, Anna-Lena; Bastidas-Ponce, Aimée; Sabrautzki, Sibylle; Tarquis-Medina, Marta; Sachs, Stephan; Rubey, Marina; Lorenz-Depiereux, Bettina; Feuchtinger, Annette; Bakhti, Mostafa; Lickert, Heiko; Przemeck, Gerhard K H; Hrabe de Angelis, Martin.
Affiliation
  • Chhabra NF; Helmholtz Zentrum München, Institute of Experimental Genetics and German Mouse Clinic, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany.
  • Amend AL; Helmholtz Zentrum München, Institute of Experimental Genetics and German Mouse Clinic, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany.
  • Bastidas-Ponce A; German Center for Diabetes Research (DZD), Neuherberg, Germany; Helmholtz Zentrum München, Institute of Diabetes and Regeneration Research, Neuherberg, Germany; Technische Universität München, School of Medicine, Munich, Germany.
  • Sabrautzki S; Helmholtz Zentrum München, Institute of Experimental Genetics and German Mouse Clinic, Neuherberg, Germany; Helmholtz Zentrum München, Research Unit Comparative Medicine, Neuherberg, Germany.
  • Tarquis-Medina M; German Center for Diabetes Research (DZD), Neuherberg, Germany; Helmholtz Zentrum München, Institute of Diabetes and Regeneration Research, Neuherberg, Germany; Technische Universität München, School of Medicine, Munich, Germany.
  • Sachs S; German Center for Diabetes Research (DZD), Neuherberg, Germany; Helmholtz Zentrum München, Institute of Diabetes and Regeneration Research, Neuherberg, Germany; Technische Universität München, School of Medicine, Munich, Germany.
  • Rubey M; Helmholtz Zentrum München, Institute of Experimental Genetics and German Mouse Clinic, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany.
  • Lorenz-Depiereux B; Helmholtz Zentrum München, Institute of Human Genetics, Neuherberg, Germany.
  • Feuchtinger A; Helmholtz Zentrum München, Research Unit Analytical Pathology, Neuherberg, Germany.
  • Bakhti M; German Center for Diabetes Research (DZD), Neuherberg, Germany; Helmholtz Zentrum München, Institute of Diabetes and Regeneration Research, Neuherberg, Germany.
  • Lickert H; German Center for Diabetes Research (DZD), Neuherberg, Germany; Helmholtz Zentrum München, Institute of Diabetes and Regeneration Research, Neuherberg, Germany; Technische Universität München, School of Medicine, Munich, Germany.
  • Przemeck GKH; Helmholtz Zentrum München, Institute of Experimental Genetics and German Mouse Clinic, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany.
  • Hrabe de Angelis M; Helmholtz Zentrum München, Institute of Experimental Genetics and German Mouse Clinic, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Technische Universität München, TUM School of Life Sciences (SoLS), Chair of Experimental Genetics, Freising, Germany. Electroni
Mol Metab ; 54: 101334, 2021 12.
Article in En | MEDLINE | ID: mdl-34487921
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Full text: 1 Database: MEDLINE Main subject: Protein Disulfide-Isomerases / Diabetes Mellitus / Insulin-Secreting Cells Limits: Animals Language: En Year: 2021 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Protein Disulfide-Isomerases / Diabetes Mellitus / Insulin-Secreting Cells Limits: Animals Language: En Year: 2021 Type: Article