Discoidin Domain Receptor 2 Regulates AT1R Expression in Angiotensin II-Stimulated Cardiac Fibroblasts via Fibronectin-Dependent Integrin-ß1 Signaling.

Titus, Allen Sam; Venugopal, Harikrishnan; Ushakumary, Mereena George; Wang, Mingyi; Cowling, Randy T; Lakatta, Edward G; Kailasam, Shivakumar

Titus, Allen Sam; Venugopal, Harikrishnan; Ushakumary, Mereena George; Wang, Mingyi; Cowling, Randy T; Lakatta, Edward G; Kailasam, Shivakumar.

Affiliation

Titus AS; Division of Cellular and Molecular Cardiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum 695011, Kerala, India.
Venugopal H; Division of Cellular and Molecular Cardiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum 695011, Kerala, India.
Ushakumary MG; Division of Cellular and Molecular Cardiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum 695011, Kerala, India.
Wang M; Laboratory of Cardiovascular Science, National Institute on Aging/National Institutes of Health, Baltimore, MD 21224, USA.
Cowling RT; Division of Cardiovascular Medicine, Department of Medicine, University of California, La Jolla, CA 92093, USA.
Lakatta EG; Laboratory of Cardiovascular Science, National Institute on Aging/National Institutes of Health, Baltimore, MD 21224, USA.
Kailasam S; Division of Cellular and Molecular Cardiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum 695011, Kerala, India.

Int J Mol Sci ; 22(17)2021 Aug 28.

Article in En | MEDLINE | ID: mdl-34502259

Subject(s)

Discoidin Domain Receptor 2/deficiency; Discoidin Domain Receptor 2/metabolism; Fibroblasts/metabolism; Fibronectins/metabolism; Integrin beta1/metabolism; Myocardium/metabolism; Receptor, Angiotensin, Type 1/metabolism; Angiotensin II/pharmacology; Animals; Apoptosis/genetics; Baculoviral IAP Repeat-Containing 3 Protein/metabolism; Collagen Type I/antagonists & inhibitors; Collagen Type I/metabolism; Discoidin Domain Receptor 2/genetics; Fibroblasts/drug effects; Fibronectins/genetics; Gene Knockdown Techniques; Gene Silencing; Heart/drug effects; Intracellular Signaling Peptides and Proteins/antagonists & inhibitors; Male; Mice; Mice, Knockout; Primary Cell Culture; Protein Serine-Threonine Kinases/metabolism; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1/genetics; Signal Transduction; YAP-Signaling Proteins

Key words

AT1 receptor; DDR2; Integrin-ß1; angiotensin II; cIAP2; cardiac fibroblasts; collagen I; fibronectin

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Full text: 1 Database: MEDLINE Main subject: Fibronectins / Integrin beta1 / Receptor, Angiotensin, Type 1 / Fibroblasts / Discoidin Domain Receptor 2 / Myocardium Limits: Animals Language: En Year: 2021 Type: Article

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