Estimating HLA haplotype frequencies from homozygous individuals - A Technical Report.

Seitz, Susanne; Lange, Vinzenz; Norman, Paul J; Sauter, Jürgen; Schmidt, Alexander H

Seitz, Susanne; Lange, Vinzenz; Norman, Paul J; Sauter, Jürgen; Schmidt, Alexander H.

Affiliation

Seitz S; DKMS, Tübingen, Germany.
Lange V; DKMS Life Science Lab, Dresden, Germany.
Norman PJ; Division of Biomedical Informatics and Personalized Medicine, Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Sauter J; DKMS, Tübingen, Germany.
Schmidt AH; DKMS, Tübingen, Germany.

Int J Immunogenet ; 48(6): 490-495, 2021 Dec.

Article in En | MEDLINE | ID: mdl-34570965

ABSTRACT

ABSTRACT

We estimated HLA haplotype frequencies based on individuals homozygous for 4, 5 or 6 loci. Validation of our approach using a sample of over 3.4 million German individuals was successful. Compared to an expectation-maximization algorithm, the errors were larger. However, our approach allows the unequivocal detection of rare haplotypes.

Subject(s)

HLA Antigens; Alleles; Gene Frequency; HLA Antigens/genetics; Haplotypes/genetics; Humans; Registries

Key words

HLA; allele frequency; donor registry; haplotype frequency; homozygosity

Fulltext

XML

PubMed Links

Search on Google