A plasma fatty acid profile associated to type 2 diabetes development: from the CORDIOPREV study.
Eur J Nutr
; 61(2): 843-857, 2022 Mar.
Article
in En
| MEDLINE
| ID: mdl-34609622
ABSTRACT
PURPOSE:
The prevalence of type 2 diabetes mellitus (T2DM) is increasing worldwide. For this reason, it is essential to identify biomarkers for the early detection of T2DM risk and/or for a better prognosis of T2DM. We aimed to identify a plasma fatty acid (FA) profile associated with T2DM development.METHODS:
We included 462 coronary heart disease patients from the CORDIOPREV study without T2DM at baseline. Of these, 107 patients developed T2DM according to the American Diabetes Association (ADA) diagnosis criteria after a median follow-up of 60 months. We performed a random classification of patients in a training set, used to build a FA Score, and a Validation set, in which we tested the FA Score.RESULTS:
FA selection with the highest prediction power was performed by random survival forest in the Training set, which yielded 4 out of the 24 FA myristic, petroselinic, α-linolenic and arachidonic acids. We built a FA Score with the selected FA and observed that patients with a higher score presented a greater risk of T2DM development, with an HR of 3.15 (95% CI 2.04-3.37) in the Training set, and an HR of 2.14 (95% CI 1.50-2.84) in the Validation set, per standard deviation (SD) increase. Moreover, patients with a higher FA Score presented lower insulin sensitivity and higher hepatic insulin resistance (p < 0.05).CONCLUSION:
Our results suggest that a detrimental FA plasma profile precedes the development of T2DM in patients with coronary heart disease, and that this FA profile can, therefore, be used as a predictive biomarker. CLINICAL TRIALS.GOV. IDENTIFIER NCT00924937.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Insulin Resistance
/
Coronary Disease
/
Diabetes Mellitus, Type 2
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limits:
Humans
Language:
En
Year:
2022
Type:
Article