Impact of Simulated Intestinal Fluids on Dissolution, Solution Chemistry, and Membrane Transport of Amorphous Multidrug Formulations.

El Sayed, Mira; Alhalaweh, Amjad; Bergström, Christel A S.

Affiliation

El Sayed M; Department of Pharmacy, Biomedical Centre, Uppsala University, P.O. Box 580, Uppsala SE-751 23, Sweden.
Alhalaweh A; Recipharm OT Chemistry AB, Uppsala SE-754 50, Sweden.
Bergström CAS; Recipharm OT Chemistry AB, Uppsala SE-754 50, Sweden.

Mol Pharm ; 18(11): 4079-4089, 2021 11 01.

Article in En | MEDLINE | ID: mdl-34613730

Subject(s)

Body Fluids/chemistry; Chemistry, Pharmaceutical/methods; Administration, Oral; Atazanavir Sulfate/administration & dosage; Atazanavir Sulfate/chemistry; Atazanavir Sulfate/pharmacokinetics; Cell Membrane/metabolism; Drug Combinations; Felodipine/administration & dosage; Felodipine/chemistry; Felodipine/pharmacokinetics; Indapamide/administration & dosage; Indapamide/chemistry; Indapamide/pharmacokinetics; Intestines; Membranes, Artificial; Ritonavir/administration & dosage; Ritonavir/chemistry; Ritonavir/pharmacokinetics; Solubility

Key words

FaSSIF; amorphous; fixed dose combination; flux; membrane transport; multidrug formulations; solubility; supersaturation