PRMT5 Promotes Symmetric Dimethylation of RNA Processing Proteins and Modulates Activated T Cell Alternative Splicing and Ca<sup>2+</sup>/NFAT Signaling.

Sengupta, Shouvonik; West, Kelsi O; Sanghvi, Shridhar; Laliotis, Georgios; Agosto, Laura M; Lynch, Kristen W; Tsichlis, Philip N; Singh, Harpreet; Patrick, Kristin L; Guerau-de-Arellano, Mireia

PRMT5 Promotes Symmetric Dimethylation of RNA Processing Proteins and Modulates Activated T Cell Alternative Splicing and Ca²⁺/NFAT Signaling.

Sengupta, Shouvonik; West, Kelsi O; Sanghvi, Shridhar; Laliotis, Georgios; Agosto, Laura M; Lynch, Kristen W; Tsichlis, Philip N; Singh, Harpreet; Patrick, Kristin L; Guerau-de-Arellano, Mireia.

Affiliation

Sengupta S; School of Health and Rehabilitation Sciences, The Ohio State University, Columbus, OH.
West KO; Biomedical Sciences Graduate Program, The Ohio State University, Columbus, OH.
Sanghvi S; Department of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, TX.
Laliotis G; Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH.
Agosto LM; Molecular, Cellular, and Developmental Biology Graduate Program, The Ohio State University, Columbus.
Lynch KW; Department of Oncology, Johns Hopkins University, Baltimore, MD.
Tsichlis PN; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA.
Singh H; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA.
Patrick KL; Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH.
Guerau-de-Arellano M; The Ohio State University Comprehensive Cancer Center, Columbus, OH.

Immunohorizons ; 5(10): 884-897, 2021 10 29.

Article in En | MEDLINE | ID: mdl-34716181

Subject(s)

Alternative Splicing/immunology; CD4-Positive T-Lymphocytes/immunology; Protein-Arginine N-Methyltransferases/metabolism; TRPM Cation Channels/genetics; Animals; CD4-Positive T-Lymphocytes/metabolism; Calcium/metabolism; Cells, Cultured; Female; Gene Knockdown Techniques; Lymphocyte Activation/genetics; Male; Methylation; Mice; Models, Animal; NFATC Transcription Factors/metabolism; Primary Cell Culture; Protein-Arginine N-Methyltransferases/genetics; RNA-Seq; Receptors, Antigen, T-Cell/metabolism; Signal Transduction/genetics; Signal Transduction/immunology

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Full text: 1 Database: MEDLINE Main subject: Protein-Arginine N-Methyltransferases / CD4-Positive T-Lymphocytes / Alternative Splicing / TRPM Cation Channels Type of study: Prognostic_studies Limits: Animals Language: En Year: 2021 Type: Article

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