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P-Glycoprotein (ABCB1/MDR1) Controls Brain Penetration and Intestinal Disposition of the PARP1/2 Inhibitor Niraparib.
F Martins, Margarida L; Loos, Nancy H C; Mucuk, Sümeyra; de Jong, Danielle; Lebre, Maria C; Rosing, Hilde; Tibben, Matthijs; Beijnen, Jos H; Schinkel, Alfred H.
Affiliation
  • F Martins ML; Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
  • Loos NHC; Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
  • Mucuk S; Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
  • de Jong D; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
  • Lebre MC; Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
  • Rosing H; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
  • Tibben M; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
  • Beijnen JH; Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
  • Schinkel AH; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
Mol Pharm ; 18(12): 4371-4384, 2021 12 06.
Article in En | MEDLINE | ID: mdl-34730366
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Full text: 1 Database: MEDLINE Main subject: Piperidines / Brain / ATP Binding Cassette Transporter, Subfamily B, Member 1 / Poly(ADP-ribose) Polymerase Inhibitors / Indazoles / Intestines Type of study: Prognostic_studies Limits: Animals Language: En Year: 2021 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Piperidines / Brain / ATP Binding Cassette Transporter, Subfamily B, Member 1 / Poly(ADP-ribose) Polymerase Inhibitors / Indazoles / Intestines Type of study: Prognostic_studies Limits: Animals Language: En Year: 2021 Type: Article