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Histone H3.3 K27M and K36M mutations de-repress transposable elements through perturbation of antagonistic chromatin marks.
Chaouch, Amel; Berlandi, Johannes; Chen, Carol C L; Frey, Felice; Badini, Shireen; Harutyunyan, Ashot S; Chen, Xiao; Krug, Brian; Hébert, Steven; Jeibmann, Astrid; Lu, Chao; Kleinman, Claudia L; Hasselblatt, Martin; Lasko, Paul; Shirinian, Margret; Jabado, Nada.
Affiliation
  • Chaouch A; Department of Biology, McGill University, Montreal, QC, Canada.
  • Berlandi J; Institute of Neuropathology, University Hospital Münster, Münster, Germany.
  • Chen CCL; Department of Human Genetics, McGill University, Montreal, QC, Canada.
  • Frey F; Department of Experimental Pathology, Immunology and Microbiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
  • Badini S; Department of Experimental Pathology, Immunology and Microbiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
  • Harutyunyan AS; Department of Human Genetics, McGill University, Montreal, QC, Canada.
  • Chen X; Department of Genetics and Development, Columbia University, New York, NY, USA.
  • Krug B; Department of Human Genetics, McGill University, Montreal, QC, Canada.
  • Hébert S; The Lady Davis Institute, Jewish General Hospital, Montreal, QC, Canada.
  • Jeibmann A; Institute of Neuropathology, University Hospital Münster, Münster, Germany.
  • Lu C; Department of Genetics and Development, Columbia University, New York, NY, USA.
  • Kleinman CL; Department of Human Genetics, McGill University, Montreal, QC, Canada; The Lady Davis Institute, Jewish General Hospital, Montreal, QC, Canada.
  • Hasselblatt M; Institute of Neuropathology, University Hospital Münster, Münster, Germany.
  • Lasko P; Department of Biology, McGill University, Montreal, QC, Canada; Department of Human Genetics, Radboud University Medical Centre, Nijmegen, the Netherlands. Electronic address: paul.lasko@mcgill.ca.
  • Shirinian M; Department of Experimental Pathology, Immunology and Microbiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon. Electronic address: ms241@aub.edu.lb.
  • Jabado N; Department of Human Genetics, McGill University, Montreal, QC, Canada; Department of Paediatrics, McGill University and the Research Institute of the McGill University Health Center, Montreal, QC, Canada. Electronic address: nada.jabado@mcgill.ca.
Mol Cell ; 81(23): 4876-4890.e7, 2021 12 02.
Article in En | MEDLINE | ID: mdl-34739871
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Full text: 1 Database: MEDLINE Main subject: Chromatin / DNA Transposable Elements / Histones / Imaginal Discs / Mutation Limits: Animals / Humans Language: En Year: 2021 Type: Article
Fulltext
Print
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PubMed Links
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Full text: 1 Database: MEDLINE Main subject: Chromatin / DNA Transposable Elements / Histones / Imaginal Discs / Mutation Limits: Animals / Humans Language: En Year: 2021 Type: Article