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Effects of a physical activity intervention on brain atrophy in older adults at risk of dementia: a randomized controlled trial.
Sinclair, Benjamin; Steward, Chris; Venkatraman, Vijay; Aljondi, Rowa; Cox, Kay L; Ellis, Kathryn A; Ames, David; Masters, Colin L; Phal, Pramit M; Sharman, Matthew J; Cyarto, Elizabeth V; Lai, Michelle M Y; Szoeke, Cassandra; Lautenschlager, Nicola T; Desmond, Patricia M.
Affiliation
  • Sinclair B; Department of Radiology, University of Melbourne, Melbourne, Australia. benjamin.james.sinclair@gmail.com.
  • Steward C; University of Melbourne, Melbourne, Australia. benjamin.james.sinclair@gmail.com.
  • Venkatraman V; Department of Neuroscience, Monash University, Melbourne, Australia. benjamin.james.sinclair@gmail.com.
  • Aljondi R; Alfred Health, Melbourne, Australia. benjamin.james.sinclair@gmail.com.
  • Cox KL; Department of Radiology, University of Melbourne, Melbourne, Australia.
  • Ellis KA; University of Melbourne, Melbourne, Australia.
  • Ames D; Department of Radiology, University of Melbourne, Melbourne, Australia.
  • Masters CL; University of Melbourne, Melbourne, Australia.
  • Phal PM; Department of Radiology, University of Melbourne, Melbourne, Australia.
  • Sharman MJ; University of Melbourne, Melbourne, Australia.
  • Cyarto EV; College of Applied Medical Sciences, Department of Applied Radiologic Technology, University of Jeddah, Jeddah, Saudi Arabia.
  • Lai MMY; Medical School, University of Western Australia, Perth, Australia.
  • Szoeke C; Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Melbourne, Australia.
  • Lautenschlager NT; Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, Australia.
  • Desmond PM; Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Melbourne, Australia.
Brain Imaging Behav ; 15(6): 2833-2842, 2021 Dec.
Article in En | MEDLINE | ID: mdl-34757564
ABSTRACT
Lack of physical activity is a risk factor for dementia, however, the utility of interventional physical activity programs as a protective measure against brain atrophy and cognitive decline is uncertain. Here we present the effect of a randomized controlled trial of a 24-month physical activity intervention on global and regional brain atrophy as characterized by longitudinal voxel-based morphometry with T1-weighted MRI images. The study sample consisted of 98 participants at risk of dementia, with mild cognitive impairment or subjective memory complaints, and having at least one vascular risk factor for dementia, randomized into an exercise group and a control group. Between 0 and 24 months, there was no significant difference detected between groups in the rate of change in global, or regional brain volumes.
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Full text: 1 Database: MEDLINE Main subject: Dementia / Cognitive Dysfunction Type of study: Clinical_trials / Etiology_studies / Risk_factors_studies Limits: Aged / Humans Language: En Year: 2021 Type: Article
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PubMed Links
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Full text: 1 Database: MEDLINE Main subject: Dementia / Cognitive Dysfunction Type of study: Clinical_trials / Etiology_studies / Risk_factors_studies Limits: Aged / Humans Language: En Year: 2021 Type: Article