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The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study.
Berthold, Erin C; Kamble, Shyam H; Raju, Kanumuri S; Kuntz, Michelle A; Senetra, Alexandria S; Mottinelli, Marco; León, Francisco; Restrepo, Luis F; Patel, Avi; Ho, Nicholas P; Hiranita, Takato; Sharma, Abhisheak; McMahon, Lance R; McCurdy, Christopher R.
Affiliation
  • Berthold EC; Department of Pharmaceutics, College of Pharmacy, (E.C.B., S.H.K., K.S.R., M.A.K., A.S.S., A.S., C.R.M.), Translational Drug Development Core, Clinical and Translational Science Institute (S.H.K., K.S.R., A.S., C.R.M.), Department of Medicinal Chemistry, College of Pharmacy (M.M., F.L., C.R.M.), and
  • Kamble SH; Department of Pharmaceutics, College of Pharmacy, (E.C.B., S.H.K., K.S.R., M.A.K., A.S.S., A.S., C.R.M.), Translational Drug Development Core, Clinical and Translational Science Institute (S.H.K., K.S.R., A.S., C.R.M.), Department of Medicinal Chemistry, College of Pharmacy (M.M., F.L., C.R.M.), and
  • Raju KS; Department of Pharmaceutics, College of Pharmacy, (E.C.B., S.H.K., K.S.R., M.A.K., A.S.S., A.S., C.R.M.), Translational Drug Development Core, Clinical and Translational Science Institute (S.H.K., K.S.R., A.S., C.R.M.), Department of Medicinal Chemistry, College of Pharmacy (M.M., F.L., C.R.M.), and
  • Kuntz MA; Department of Pharmaceutics, College of Pharmacy, (E.C.B., S.H.K., K.S.R., M.A.K., A.S.S., A.S., C.R.M.), Translational Drug Development Core, Clinical and Translational Science Institute (S.H.K., K.S.R., A.S., C.R.M.), Department of Medicinal Chemistry, College of Pharmacy (M.M., F.L., C.R.M.), and
  • Senetra AS; Department of Pharmaceutics, College of Pharmacy, (E.C.B., S.H.K., K.S.R., M.A.K., A.S.S., A.S., C.R.M.), Translational Drug Development Core, Clinical and Translational Science Institute (S.H.K., K.S.R., A.S., C.R.M.), Department of Medicinal Chemistry, College of Pharmacy (M.M., F.L., C.R.M.), and
  • Mottinelli M; Department of Pharmaceutics, College of Pharmacy, (E.C.B., S.H.K., K.S.R., M.A.K., A.S.S., A.S., C.R.M.), Translational Drug Development Core, Clinical and Translational Science Institute (S.H.K., K.S.R., A.S., C.R.M.), Department of Medicinal Chemistry, College of Pharmacy (M.M., F.L., C.R.M.), and
  • León F; Department of Pharmaceutics, College of Pharmacy, (E.C.B., S.H.K., K.S.R., M.A.K., A.S.S., A.S., C.R.M.), Translational Drug Development Core, Clinical and Translational Science Institute (S.H.K., K.S.R., A.S., C.R.M.), Department of Medicinal Chemistry, College of Pharmacy (M.M., F.L., C.R.M.), and
  • Restrepo LF; Department of Pharmaceutics, College of Pharmacy, (E.C.B., S.H.K., K.S.R., M.A.K., A.S.S., A.S., C.R.M.), Translational Drug Development Core, Clinical and Translational Science Institute (S.H.K., K.S.R., A.S., C.R.M.), Department of Medicinal Chemistry, College of Pharmacy (M.M., F.L., C.R.M.), and
  • Patel A; Department of Pharmaceutics, College of Pharmacy, (E.C.B., S.H.K., K.S.R., M.A.K., A.S.S., A.S., C.R.M.), Translational Drug Development Core, Clinical and Translational Science Institute (S.H.K., K.S.R., A.S., C.R.M.), Department of Medicinal Chemistry, College of Pharmacy (M.M., F.L., C.R.M.), and
  • Ho NP; Department of Pharmaceutics, College of Pharmacy, (E.C.B., S.H.K., K.S.R., M.A.K., A.S.S., A.S., C.R.M.), Translational Drug Development Core, Clinical and Translational Science Institute (S.H.K., K.S.R., A.S., C.R.M.), Department of Medicinal Chemistry, College of Pharmacy (M.M., F.L., C.R.M.), and
  • Hiranita T; Department of Pharmaceutics, College of Pharmacy, (E.C.B., S.H.K., K.S.R., M.A.K., A.S.S., A.S., C.R.M.), Translational Drug Development Core, Clinical and Translational Science Institute (S.H.K., K.S.R., A.S., C.R.M.), Department of Medicinal Chemistry, College of Pharmacy (M.M., F.L., C.R.M.), and
  • Sharma A; Department of Pharmaceutics, College of Pharmacy, (E.C.B., S.H.K., K.S.R., M.A.K., A.S.S., A.S., C.R.M.), Translational Drug Development Core, Clinical and Translational Science Institute (S.H.K., K.S.R., A.S., C.R.M.), Department of Medicinal Chemistry, College of Pharmacy (M.M., F.L., C.R.M.), and
  • McMahon LR; Department of Pharmaceutics, College of Pharmacy, (E.C.B., S.H.K., K.S.R., M.A.K., A.S.S., A.S., C.R.M.), Translational Drug Development Core, Clinical and Translational Science Institute (S.H.K., K.S.R., A.S., C.R.M.), Department of Medicinal Chemistry, College of Pharmacy (M.M., F.L., C.R.M.), and
  • McCurdy CR; Department of Pharmaceutics, College of Pharmacy, (E.C.B., S.H.K., K.S.R., M.A.K., A.S.S., A.S., C.R.M.), Translational Drug Development Core, Clinical and Translational Science Institute (S.H.K., K.S.R., A.S., C.R.M.), Department of Medicinal Chemistry, College of Pharmacy (M.M., F.L., C.R.M.), and
Drug Metab Dispos ; 50(2): 158-167, 2022 02.
Article in En | MEDLINE | ID: mdl-34759012
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Full text: 1 Database: MEDLINE Main subject: Secologanin Tryptamine Alkaloids Type of study: Prognostic_studies Limits: Animals Language: En Year: 2022 Type: Article
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Secologanin Tryptamine Alkaloids Type of study: Prognostic_studies Limits: Animals Language: En Year: 2022 Type: Article