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Radiation therapy in the prevention and management of brain metastases in patients with small cell lung cancer: a narrative review.
Hau, Eric; Lim, Rebecca; Vinod, Shalini; Nahar, Najmun; Gee, Harriet; Pinkham, Mark B.
Affiliation
  • Hau E; Sydney West Radiation Oncology Network, Sydney, Australia; Westmead Clinical School, University of Sydney, Sydney, Australia; Westmead Institute of Medical Research, Sydney, Australia.
  • Lim R; Department of Radiology, Westmead hospital, Sydney, Australia.
  • Vinod S; Liverpool Cancer Therapy Centre, Liverpool, Australia; South Western Sydney Clinical School, UNSW & Ingham Institute for Applied Medical Research, Liverpool, Australia.
  • Nahar N; Sydney West Radiation Oncology Network, Sydney, Australia.
  • Gee H; Sydney West Radiation Oncology Network, Sydney, Australia; Children's Medical Research Institute, Sydney, Australia; University of Sydney, Sydney, Australia.
  • Pinkham MB; Radiation Oncology, Cancer Services, Princess Alexandra Hospital, Brisbane, Australia; School of Medicine, University of Queensland, Brisbane, Australia.
Chin Clin Oncol ; 11(2): 12, 2022 Apr.
Article in En | MEDLINE | ID: mdl-34775779
ABSTRACT

OBJECTIVE:

The purpose of this narrative review is to survey the current literature and provide treatment recommendations for the management of patients with brain metastases (BMs) from small cell lung cancer (SCLC).

BACKGROUND:

BMs are very common in patients with SCLC and management has changed significantly in recent years. Radiation techniques and systemic therapies have evolved and this review will highlight these recent studies and implications on clinical practice.

METHODS:

This narrative review covers prophylaxis and treatment of established BMs in patients with SCLC. Studies included are based on Medline, PubMed, Google scholar searches, abstracts from conference proceedings and references from published papers.

CONCLUSIONS:

Radiation therapy continue to have an important role in the prophylaxis and treatment of patients with BMs. Radiation technologies have resulted in significant reduction of toxicities and improved quality of life (QoL). There continues to be many unanswered questions and results of currently accruing trials will hopefully fill some of these gaps and refine the role of radiation therapy in the management of this condition.
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Full text: 1 Database: MEDLINE Main subject: Brain Neoplasms / Radiosurgery / Small Cell Lung Carcinoma / Lung Neoplasms Type of study: Guideline / Systematic_reviews Limits: Humans Language: En Year: 2022 Type: Article
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Brain Neoplasms / Radiosurgery / Small Cell Lung Carcinoma / Lung Neoplasms Type of study: Guideline / Systematic_reviews Limits: Humans Language: En Year: 2022 Type: Article