Mechanism of PINK1 activation by autophosphorylation and insights into assembly on the TOM complex.

Rasool, Shafqat; Veyron, Simon; Soya, Naoto; Eldeeb, Mohamed A; Lukacs, Gergely L; Fon, Edward A; Trempe, Jean-François

Rasool, Shafqat; Veyron, Simon; Soya, Naoto; Eldeeb, Mohamed A; Lukacs, Gergely L; Fon, Edward A; Trempe, Jean-François.

Affiliation

Rasool S; Department of Pharmacology & Therapeutics and Centre de Recherche en Biologie Structurale, McGill University, Montréal, QC, Canada.
Veyron S; Department of Pharmacology & Therapeutics and Centre de Recherche en Biologie Structurale, McGill University, Montréal, QC, Canada.
Soya N; Department of Physiology and Centre de Recherche en Biologie Structurale, McGill University, Montréal, QC, Canada.
Eldeeb MA; McGill Parkinson Program and Neurodegenerative Diseases Group, Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada.
Lukacs GL; Department of Physiology and Centre de Recherche en Biologie Structurale, McGill University, Montréal, QC, Canada.
Fon EA; McGill Parkinson Program and Neurodegenerative Diseases Group, Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada.
Trempe JF; Department of Pharmacology & Therapeutics and Centre de Recherche en Biologie Structurale, McGill University, Montréal, QC, Canada. Electronic address: jeanfrancois.trempe@mcgill.ca.

Mol Cell ; 82(1): 44-59.e6, 2022 01 06.

Article in En | MEDLINE | ID: mdl-34875213

Subject(s)

Insect Proteins/metabolism; Mitochondria/enzymology; Mitochondrial Precursor Protein Import Complex Proteins/metabolism; Protein Kinases/metabolism; Tribolium/enzymology; Animals; Cell Line, Tumor; Enzyme Activation; Enzyme Stability; Humans; Insect Proteins/genetics; Kinetics; Mitochondria/genetics; Mitochondrial Precursor Protein Import Complex Proteins/genetics; Molecular Docking Simulation; Mutation; Phosphorylation; Protein Interaction Domains and Motifs; Protein Kinases/genetics; Structure-Activity Relationship; Tribolium/genetics

Key words

PINK1; Parkin; Parkinson; TOM; X-ray crystallography; kinase; mass spectrometry; mitochondria; phosphorylation; ubiquitin

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Full text: 1 Database: MEDLINE Main subject: Protein Kinases / Tribolium / Insect Proteins / Mitochondrial Precursor Protein Import Complex Proteins / Mitochondria Limits: Animals / Humans Language: En Year: 2022 Type: Article

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