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Microgravity and space radiation inhibit autophagy in human capillary endothelial cells, through either opposite or synergistic effects on specific molecular pathways.
Barravecchia, Ivana; De Cesari, Chiara; Forcato, Mattia; Scebba, Francesca; Pyankova, Olga V; Bridger, Joanna M; Foster, Helen A; Signore, Giovanni; Borghini, Andrea; Andreassi, Mariagrazia; Andreazzoli, Massimiliano; Bicciato, Silvio; Pè, Mario Enrico; Angeloni, Debora.
Affiliation
  • Barravecchia I; Institute of Life Sciences, Scuola Superiore Sant'Anna, Via G. Moruzzi, 1, 56124, Pisa, Italy.
  • De Cesari C; Department of Pharmacy, University of Pisa, 56126, Pisa, Italy.
  • Forcato M; Institute of Life Sciences, Scuola Superiore Sant'Anna, Via G. Moruzzi, 1, 56124, Pisa, Italy.
  • Scebba F; Department of Biology, University of Pisa, 56123, Pisa, Italy.
  • Pyankova OV; Center for Genome Research, Department of Life Science, University of Modena and Reggio Emilia, 41125, Modena, Italy.
  • Bridger JM; Institute of Life Sciences, Scuola Superiore Sant'Anna, Via G. Moruzzi, 1, 56124, Pisa, Italy.
  • Foster HA; Institute of Life Sciences, Scuola Superiore Sant'Anna, Via G. Moruzzi, 1, 56124, Pisa, Italy.
  • Signore G; Laboratory of Nuclear and Genomic Health, Centre of Genome Engineering and Maintenance, Division of Biosciences, Department of Life Sciences, College of Health and Life Sciences, Brunel University London, Uxbridge, UB8 3PH, UK.
  • Borghini A; Department of Biological and Environmental Sciences, School of Life and Medical Sciences, University of Hertfordshire, Hatfield, UK.
  • Andreassi M; Fondazione Pisana Per La Scienza, 56124, Pisa, Italy.
  • Andreazzoli M; Institute of Clinical Physiology, National Research Council, 56124, Pisa, Italy.
  • Bicciato S; Institute of Clinical Physiology, National Research Council, 56124, Pisa, Italy.
  • Pè ME; Department of Biology, University of Pisa, 56123, Pisa, Italy.
  • Angeloni D; Center for Genome Research, Department of Life Science, University of Modena and Reggio Emilia, 41125, Modena, Italy.
Cell Mol Life Sci ; 79(1): 28, 2021 Dec 22.
Article in En | MEDLINE | ID: mdl-34936031
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Full text: 1 Database: MEDLINE Main subject: Autophagy / Weightlessness / Capillaries / Signal Transduction / Cosmic Radiation / Endothelial Cells Type of study: Prognostic_studies Limits: Humans / Male Language: En Year: 2021 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Autophagy / Weightlessness / Capillaries / Signal Transduction / Cosmic Radiation / Endothelial Cells Type of study: Prognostic_studies Limits: Humans / Male Language: En Year: 2021 Type: Article