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Manifesto on inhaled triple therapy in asthma: an Interasma (Global Asthma Association - GAA) document.
Braido, Fulvio; Tiotiu, Angelica; Guidos-Fogelbach, Guillermo; Baiardini, Ilaria; Cosini, Filippo; Correia de Sousa, Jaime; Bikov, Andras; Novakova, Sylvia; Labor, Marina; Kaidashev, Igor; Nedeva, Denislava; Kowal, Krzysztof; Mihaicuta, Stefan; Urrutia Pereira, Marilyn; Solé, Dirceu; Novakova, Plamela; Chong-Neto, Herberto; Vrzy, Laura; Ansotegui, Ignacio J; Bernstein, Jonathan A; Boulet, Louis-Philippe; Canonica, Giorgio Walter; Dubuske, Lawrence; Nunes, Carlos; Ivancevich, Juan Carlos; Santus, Pierachille; Rosario, Nelson; Emelyanov, Alexander; Steiropoulos, Paschalis.
Affiliation
  • Braido F; IRCCS, Ospedale Policlinico San Martino, Genova, Italy.
  • Tiotiu A; Department of Internal Medicine, University of Genoa, Genova, Italy.
  • Guidos-Fogelbach G; Department of Pulmonology, University Hospital of Nancy, Nancy, France.
  • Baiardini I; EA 3450 DevAH - Development, Adaptation and Disadvantage, Cardiorespiratory Regulations and Motor Control, University of Lorraine, Nancy, France.
  • Cosini F; Instituto Politécnico Nacional, E.N.M.H/S.E.P.I, Laboratorio de Bioquímica Estructural, Ciudad de México, México.
  • Correia de Sousa J; Department of Internal Medicine, University of Genoa, Genova, Italy.
  • Bikov A; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
  • Novakova S; IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
  • Labor M; University of Genoa, Genova, Italy.
  • Kaidashev I; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
  • Nedeva D; ICVS/3B's, PT Government Associate Laboratory, Braga/Guimarães, Portugal.
  • Kowal K; Manchester University NHS Foundation Trust, Manchester, UK.
  • Mihaicuta S; Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester, UK.
  • Urrutia Pereira M; Allergy Unit of Internal Consulting Department, University Hospital "St. George", Plovdiv, Bulgaria.
  • Solé D; Värnamo Hospital, Värnamo, Sweden.
  • Novakova P; Ukrainian Medical Stomatological Academy, Poltava, Ukraine.
  • Chong-Neto H; Medical University Sofia, Sofia, Bulgaria.
  • Vrzy L; Department of Allergology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland.
  • Ansotegui IJ; Pulmonology Department, Cardio Prevent Foundation, University of Medicine and Pharmacy "Dr Victor Babes", Timisoara, Romania.
  • Bernstein JA; Federal University of Pampa - Campus Uruguaiana, Pediatic Program of Asthma Prevention (PIPA), Pontifícia Universidade Católica do Rio Grande do Sul, Universidad Nacional de Córdoba, Córdoba, Argentina.
  • Boulet LP; Associação Brasileira de Alergia e Imunologia, Sociedade Brasileira de Pediatria, Universidade Federal de São Paulo, São Paulo, Brazil.
  • Canonica GW; Clinic of Clinical Allergy, Medical University, Sofia, Bulgaria.
  • Dubuske L; Division of Allergy and Immunology, Department of Pediatrics, Federal University of Paraná, Curitiba, Brazil.
  • Nunes C; University of Genoa, Genova, Italy.
  • Ivancevich JC; Hospital Quirónsalud Bizkaia, Bilbao, Spain.
  • Santus P; Division of Immunology, Department of Internal Medicine, Allergy Section University of Cincinnati, Cincinnati, OH, USA.
  • Rosario N; Québec Heart and Lung Institute-Laval University, Québec City, Canada.
  • Emelyanov A; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
  • Steiropoulos P; IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
J Asthma ; 59(12): 2402-2412, 2022 12.
Article in En | MEDLINE | ID: mdl-34936532
ABSTRACT

Objective:

The optimal use of drug combinations for the management of asthma is providing significant results. This has prompted Interasma (Global Asthma Association) to take a position on inhaled triple therapy in asthma.

Methods:

We performed an extensive literature research to clinical trials, meta-analyses, randomized controlled trials and systematic reviews.

Results:

Starting from an extensive literature review, Interasma executive committee discussed and approved this Manifesto, developed by Interasma scientific network (INES) members.

Conclusions:

The manifesto describes the evidence gathered to date and states, advocates, and proposes issues on inhaled corticosteroid (ICS) plus long-acting beta 2 agonist (LABA) and long-acting muscarinic antagonists (LAMA) with the aim of challenging assumptions, fostering commitment, and bringing about change.
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Full text: 1 Database: MEDLINE Main subject: Asthma / Pulmonary Disease, Chronic Obstructive Type of study: Clinical_trials / Risk_factors_studies Limits: Humans Language: En Year: 2022 Type: Article
Fulltext
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PubMed Links
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Full text: 1 Database: MEDLINE Main subject: Asthma / Pulmonary Disease, Chronic Obstructive Type of study: Clinical_trials / Risk_factors_studies Limits: Humans Language: En Year: 2022 Type: Article