Antiviral activity of aframomum melegueta against severe acute respiratory syndrome coronaviruses type 1 and 2.

Mahoney, Oneil; Melo, Claudia; Lockhart, Anthony; Cornejal, Nadjet; Alsaidi, Sahar; Wu, Qingli; Simon, Jim; Juliani, Rodolfo; Zydowsky, Thomas M; Priano, Christine; Koroch, Adolfina; Fernández Romero, José A.

Affiliation

Mahoney O; Science Department, Borough of Manhattan Community College, The City University of New York, NY, 199 Chambers Street, Science Department room N699, New York, NY 10007, USA.
Melo C; George Washington University, Washington DC USA.
Lockhart A; Rutgers University, New Brunswick, NJ USA.
Cornejal N; Brooklyn College, The City University of New York, NY USA.
Alsaidi S; Lehman College, The City University of New York, NY USA.
Wu Q; Rutgers University, New Brunswick, NJ USA.
Simon J; Rutgers University, New Brunswick, NJ USA.
Juliani R; Rutgers University, New Brunswick, NJ USA.
Zydowsky TM; Center for Biomedical Research, Population Council, New York, NY USA.
Priano C; Science Department, Borough of Manhattan Community College, The City University of New York, NY, 199 Chambers Street, Science Department room N699, New York, NY 10007, USA.
Koroch A; Science Department, Borough of Manhattan Community College, The City University of New York, NY, 199 Chambers Street, Science Department room N699, New York, NY 10007, USA.
Fernández Romero JA; Science Department, Borough of Manhattan Community College, The City University of New York, NY, 199 Chambers Street, Science Department room N699, New York, NY 10007, USA.

S Afr J Bot ; 146: 735-739, 2022 May.

Article in En | MEDLINE | ID: mdl-34955582

Key words

Antiviral; CC50, half-maximal cytotoxic concentration; CI, Combination Index; COVID-19, Coronavirus disease 2019; EC50, half-maximal effective concentration; Gingerols; METLIM, Metabolomics Database and Library; PCDL, comprehensive database of metabolites that includes MS/MS spectra; Phytotherapy; PsV, pseudovirus; QTOF/MS, quadrupole technologies with a time-of-flight mass analyser; SARS-COV-2; SARS-CoV-2, Severe Acute Respiratory Syndrome Coronavirus 2; SE, Seed Extract; TI, Therapeutic index; UPLC/DAD, ultra-performance liquid chromatography method with diode array detection; XTT, 2,3-Bis-(2-Methoxy-4-Nitro-5-Sulfophenyl)-2H-Tetrazolium-5-Carboxanilide; hACE-2, human angiotensin-converting enzyme 2