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Improvement of the affinity of an anti-rat P2X4 receptor antibody by introducing electrostatic interactions.
Shinozaki, Chinatsu; Kohno, Keita; Shiroishi, Mitsunori; Takahashi, Daisuke; Yoshikawa, Yu; Abe, Yoshito; Hamase, Kenji; Nakakido, Makoto; Tsumoto, Kohei; Inoue, Kazuhide; Tsuda, Makoto; Ueda, Tadashi.
Affiliation
  • Shinozaki C; Department of Protein Structure, Function and Design, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
  • Kohno K; Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi, Fukuoka, 812-8582, Japan.
  • Shiroishi M; Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi, Fukuoka, 812-8582, Japan.
  • Takahashi D; Department of Protein Structure, Function and Design, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
  • Yoshikawa Y; Department of Biological Science and Technology, Tokyo University of Science, 6-3-1 Niijuku Katsushika-ku, Tokyo, 125-8585, Japan.
  • Abe Y; Department of Protein Structure, Function and Design, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
  • Hamase K; Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi, Fukuoka, 812-8582, Japan.
  • Nakakido M; Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi, Fukuoka, 812-8582, Japan.
  • Tsumoto K; Department of Protein Structure, Function and Design, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
  • Inoue K; Department of Drug Discovery and Evolution, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
  • Tsuda M; Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.
  • Ueda T; Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.
Sci Rep ; 12(1): 131, 2022 01 07.
Article in En | MEDLINE | ID: mdl-34996944
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Full text: 1 Database: MEDLINE Main subject: Microglia / Receptors, Purinergic P2X4 / Purinergic P2X Receptor Antagonists / Antibodies, Monoclonal / Neuralgia Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Year: 2022 Type: Article
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Microglia / Receptors, Purinergic P2X4 / Purinergic P2X Receptor Antagonists / Antibodies, Monoclonal / Neuralgia Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Year: 2022 Type: Article