A Photosensitizer-Free Radical Cascade for Synthesizing CF3-Containing Polycyclic Quinazolinones with Visible Light.
J Org Chem
; 87(2): 1493-1501, 2022 01 21.
Article
in En
| MEDLINE
| ID: mdl-35014249
ABSTRACT
Herein, we report an efficient photoinduced radical tandem trifluoromethylation/cyclization reaction of N-cyanamide alkenes for the synthesis of functionalized quinazolinones. Importantly, the reaction is carried out under mild conditions without any additional photosensitizer, metal, or extra additives. A series of trifluoromethyl quinazolinones were prepared efficiently with good yields and excellent functional group tolerance. Preliminary mechanistic experiments were conducted to indicate that the transformation proceeds via a possible mechanism involving photoexcited EDA complex and chain propagation.
Full text:
1
Database:
MEDLINE
Main subject:
Photosensitizing Agents
/
Quinazolinones
Language:
En
Year:
2022
Type:
Article