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Ulotaront: A TAAR1 Agonist for the Treatment of Schizophrenia.
Heffernan, Michele L R; Herman, Lee W; Brown, Scott; Jones, Philip G; Shao, Liming; Hewitt, Michael C; Campbell, John E; Dedic, Nina; Hopkins, Seth C; Koblan, Kenneth S; Xie, Linghong.
Affiliation
  • Heffernan MLR; Sunovion Pharmaceuticals Inc, Marlborough, Massachusetts 01752, United States.
  • Herman LW; Sunovion Pharmaceuticals Inc, Marlborough, Massachusetts 01752, United States.
  • Brown S; Sunovion Pharmaceuticals Inc, Marlborough, Massachusetts 01752, United States.
  • Jones PG; Sunovion Pharmaceuticals Inc, Marlborough, Massachusetts 01752, United States.
  • Shao L; Sunovion Pharmaceuticals Inc, Marlborough, Massachusetts 01752, United States.
  • Hewitt MC; Sunovion Pharmaceuticals Inc, Marlborough, Massachusetts 01752, United States.
  • Campbell JE; Sunovion Pharmaceuticals Inc, Marlborough, Massachusetts 01752, United States.
  • Dedic N; Sunovion Pharmaceuticals Inc, Marlborough, Massachusetts 01752, United States.
  • Hopkins SC; Sunovion Pharmaceuticals Inc, Marlborough, Massachusetts 01752, United States.
  • Koblan KS; Sunovion Pharmaceuticals Inc, Marlborough, Massachusetts 01752, United States.
  • Xie L; Sunovion Pharmaceuticals Inc, Marlborough, Massachusetts 01752, United States.
ACS Med Chem Lett ; 13(1): 92-98, 2022 Jan 13.
Article in En | MEDLINE | ID: mdl-35047111
Ulotaront (SEP-363856) is a trace-amine associated receptor 1 (TAAR1) agonist with 5-HT1A receptor agonist activity in Phase 3 clinical development, with FDA Breakthrough Therapy Designation, for the treatment of schizophrenia. TAAR1 is a G-protein-coupled receptor (GPCR) that is expressed in cortical, limbic, and midbrain monoaminergic regions. It is activated by endogenous trace amines, and is believed to play an important role in modulating dopaminergic, serotonergic, and glutamatergic circuitry. TAAR1 agonism data are reported herein for ulotaront and its analogues in comparison to endogenous TAAR1 agonists. In addition, a human TAAR1 homology model was built around ulotaront to identify key interactions and attempt to better understand the scaffold-specific TAAR1 agonism structure-activity relationships.