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Lung-restricted ALK5 inhibition avoids systemic toxicities associated with TGFß pathway inhibition.
Maher, Jonathan M; Zhang, Rui; Palanisamy, Gopinath; Perkins, Kimberly; Liu, Lynda; Brassil, Patrick; McNamara, Alexander; Lo, Arthur; Hughes, Adam D; Kanodia, Jitendra; Kulyk, Svitlana; Nikula, Kristen J; Dengler, Hart S; Scandurra, Amy; Lua, Ingrid; Harstad, Eric.
Affiliation
  • Maher JM; Theravance Biopharma US, Inc., South San Francisco, CA, USA. Electronic address: JMaher@theravance.com.
  • Zhang R; Theravance Biopharma US, Inc., South San Francisco, CA, USA.
  • Palanisamy G; Olema Oncology, San Francisco, CA, USA.
  • Perkins K; Theravance Biopharma US, Inc., South San Francisco, CA, USA.
  • Liu L; Theravance Biopharma US, Inc., South San Francisco, CA, USA.
  • Brassil P; Theravance Biopharma US, Inc., South San Francisco, CA, USA.
  • McNamara A; Theravance Biopharma US, Inc., South San Francisco, CA, USA.
  • Lo A; Theravance Biopharma US, Inc., South San Francisco, CA, USA.
  • Hughes AD; Theravance Biopharma US, Inc., South San Francisco, CA, USA.
  • Kanodia J; Theravance Biopharma US, Inc., South San Francisco, CA, USA.
  • Kulyk S; Mirati Therapeutics, San Diego, CA, USA.
  • Nikula KJ; Inotiv, Maryland Heights, MO, USA.
  • Dengler HS; Interline Therapeutics, South San Francisco, CA, USA.
  • Scandurra A; Theravance Biopharma US, Inc., South San Francisco, CA, USA.
  • Lua I; Theravance Biopharma US, Inc., South San Francisco, CA, USA.
  • Harstad E; Theravance Biopharma US, Inc., South San Francisco, CA, USA.
Toxicol Appl Pharmacol ; 438: 115905, 2022 03 01.
Article in En | MEDLINE | ID: mdl-35122773
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Full text: 1 Database: MEDLINE Main subject: Signal Transduction / Receptor, Transforming Growth Factor-beta Type I / Lung Type of study: Risk_factors_studies Limits: Animals Language: En Year: 2022 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Signal Transduction / Receptor, Transforming Growth Factor-beta Type I / Lung Type of study: Risk_factors_studies Limits: Animals Language: En Year: 2022 Type: Article