Characterization of vitamin D deficiency and use of a standardized supplementation protocol in orthopaedic trauma patients.
Eur J Orthop Surg Traumatol
; 33(4): 955-960, 2023 May.
Article
in En
| MEDLINE
| ID: mdl-35230543
ABSTRACT
PURPOSE:
The objectives of this study were to assess the incidence of vitamin D deficiency in orthopaedic trauma patients, evaluate the safety and efficacy of a vitamin D supplementation protocol, and investigate the utility of vitamin D supplementation in reducing nonunions.METHODS:
Three hundred seventy patients with operative tibia and/or fibula fractures were retrospectively reviewed. Both overall and matched cohorts were analysed.RESULTS:
Ninety-eight per cent (n = 210) were found to have vitamin D insufficiency (serum 25(OH)D level < 30 ng/ml). There were no cases of vitamin D toxicity following vitamin D replacement. Median follow-up vitamin D level was 22.7 ng/mL. No statistical difference between union rates was found between either the two consecutive cohorts or matched cohorts.CONCLUSION:
This vitamin D replacement protocol was a safe treatment for hypovitaminosis D, but post hoc analysis shows there would need to be over 1200 matched patients to achieve adequate power.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Orthopedics
/
Vitamin D Deficiency
/
Fractures, Bone
Type of study:
Guideline
Limits:
Humans
Language:
En
Year:
2023
Type:
Article