Your browser doesn't support javascript.
loading
Gene fusions in gastrointestinal tract cancers.
Rahi, Hamed; Olave, Maria C; Fritchie, Karen J; Greipp, Patricia T; Halling, Kevin C; Kipp, Benjamin R; Graham, Rondell P.
Affiliation
  • Rahi H; Division of Laboratory of Genetics and Genomics, Mayo Clinic, Rochester, Minnesota, USA.
  • Olave MC; Division of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota, USA.
  • Fritchie KJ; Division of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio, USA.
  • Greipp PT; Division of Laboratory of Genetics and Genomics, Mayo Clinic, Rochester, Minnesota, USA.
  • Halling KC; Division of Laboratory of Genetics and Genomics, Mayo Clinic, Rochester, Minnesota, USA.
  • Kipp BR; Division of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota, USA.
  • Graham RP; Division of Laboratory of Genetics and Genomics, Mayo Clinic, Rochester, Minnesota, USA.
Genes Chromosomes Cancer ; 61(5): 285-297, 2022 05.
Article in En | MEDLINE | ID: mdl-35239225
Fusion genes have been identified in a wide array of human neoplasms including hematologic and solid tumors, including gastrointestinal tract neoplasia. A fusion gene is the product of parts of two genes that are joined together following a deletion, translocation, or chromosomal inversion. Together with single nucleotide variants, insertions, deletions, and amplification, fusion genes represent one of the key genomic mechanisms for tumor development. Detecting fusions in the clinic is accomplished by a variety of techniques including break-apart fluorescence in situ hybridization, reverse transcription-polymerase chain reaction, and next-generation sequencing. Some recurrent gene fusions have been successfully targeted by small molecule or monoclonal antibody therapies (ie targeted therapies), while others are used as biomarkers for diagnostic and prognostic purposes. The purpose of this review article is to discuss the clinical utility of detection of gene fusions in carcinomas and neoplasms arising primarily in the digestive system.
Subject(s)
Key words

Full text: 1 Database: MEDLINE Main subject: Gene Fusion / Gastrointestinal Neoplasms Limits: Humans Language: En Year: 2022 Type: Article

Full text: 1 Database: MEDLINE Main subject: Gene Fusion / Gastrointestinal Neoplasms Limits: Humans Language: En Year: 2022 Type: Article