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Novel biphenyl-based scaffold as potent and selective histone deacetylase 6 (HDAC6) inhibitors: Identification, development and pharmacological evaluation.
Xu, Xi; Zhang, Di; Zhao, Tengteng; Wang, Min; Li, Yu; Du, Qianming; Kou, Junping; Li, Zhiyu; Bian, Jinlei.
Affiliation
  • Xu X; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, PR China.
  • Zhang D; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, PR China.
  • Zhao T; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, PR China.
  • Wang M; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, PR China.
  • Li Y; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, PR China.
  • Du Q; General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, PR China.
  • Kou J; State Key Laboratory of Natural Products, Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Department of Pharmacology of Chinese Material Medical, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, PR China.
  • Li Z; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, PR China. Electronic address: zhiyuli@cpu.edu.cn.
  • Bian J; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, PR China. Electronic address: bianjl@cpu.edu.cn.
Eur J Med Chem ; 233: 114228, 2022 Apr 05.
Article in En | MEDLINE | ID: mdl-35245830
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Full text: 1 Database: MEDLINE Main subject: Antineoplastic Agents Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Humans Language: En Year: 2022 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Antineoplastic Agents Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Humans Language: En Year: 2022 Type: Article