Association between disease severity according to "MN criteria" and 30-day mortality in patients with Clostridioides difficile infection.
J Infect Chemother
; 28(6): 757-761, 2022 Jun.
Article
in En
| MEDLINE
| ID: mdl-35249819
ABSTRACT
INTRODUCTION:
A rapid membrane enzyme immunoassays (EIA) are frequently used to diagnose Clostridioides difficile infection (CDI). If EIA does not provide a definitive CDI diagnosis, whether treatment with anti-CD agents is to be performed depends on the pathogenesis and severity of the disease. In Japan, "MN criteria" have been proposed for the classification of disease severity. In this study, we investigated the association between disease severity and CDI prognosis when MN criteria are used.METHODS:
This study included 102 patients diagnosed with CDI between April 2015 and March 2020. The disease serverity classification accorditng to MN criteria was divided into two groups non-severely ill (mild to moderate) and severely ill (severe to critical) group.RESULTS:
Mortality was significantly higher in severely ill patients than non-severely ill patients (46.7% vs. 13.8%, p = 0.0025). Multivariable analysis showed that the mortality of patients with CDI was significantly associated with advanced age (odds ratio [OR] = 1.1; 95% confidence interval [CI] = 1.0-1.2; p = 0.019) and disease severity (OR = 4.2; 95% CI = 1.2-14.8; p = 0.023).DISCUSSION:
The classification of disease severity according to the MN criteria would be particularly useful in predicting the patients' prognoses.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Clostridioides difficile
/
Clostridium Infections
Type of study:
Diagnostic_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Year:
2022
Type:
Article