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Quality control of protein complex composition.
Padovani, Chris; Jevtic, Predrag; Rapé, Michael.
Affiliation
  • Padovani C; Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA.
  • Jevtic P; Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA 94720, USA.
  • Rapé M; Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA 94720, USA; California Institute for Quantitative Biosciences (QB3), University of California at Berkeley, Berkeley, CA 94720, USA. Electronic address: mrape@berkeley.edu.
Mol Cell ; 82(8): 1439-1450, 2022 04 21.
Article in En | MEDLINE | ID: mdl-35316660
ABSTRACT
Eukaryotic cells possess hundreds of protein complexes that contain multiple subunits and must be formed at the correct time and place during development. Despite specific assembly pathways, cells frequently encounter complexes with missing or aberrant subunits that can disrupt important signaling events. Cells, therefore, employ several ubiquitin-dependent quality control pathways that can prevent, correct, or degrade flawed complexes. In this review, we will discuss our emerging understanding of such quality control of protein complex composition.
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Full text: 1 Database: MEDLINE Main subject: Ubiquitin / Proteasome Endopeptidase Complex Language: En Year: 2022 Type: Article
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Database: MEDLINE Main subject: Ubiquitin / Proteasome Endopeptidase Complex Language: En Year: 2022 Type: Article