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Alteration of Oral and Perioral Soft Tissue in Mice following Incisor Tooth Extraction.
Takagi, Takahiro; Yamamoto, Masahito; Sugano, Aki; Kanehira, Chiemi; Kitamura, Kei; Katayama, Masateru; Sakai, Katsuhiko; Sato, Masaki; Abe, Shinichi.
Affiliation
  • Takagi T; Department of Anatomy, Tokyo Dental College, 2-9-18, Kandamisaki-cho, Chiyoda-ku, Tokyo 101-0061, Japan.
  • Yamamoto M; Department of Anatomy, Tokyo Dental College, 2-9-18, Kandamisaki-cho, Chiyoda-ku, Tokyo 101-0061, Japan.
  • Sugano A; Department of Dental Hygiene, Tokyo Dental Junior College, 2-9-18, Kandamisaki-cho, Chiyoda-ku, Tokyo 101-0061, Japan.
  • Kanehira C; Department of Anatomy, Tokyo Dental College, 2-9-18, Kandamisaki-cho, Chiyoda-ku, Tokyo 101-0061, Japan.
  • Kitamura K; Department of Histology and Developmental Biology, Tokyo Dental College, 2-9-18, Kandamisaki-cho, Chiyoda-ku, Tokyo 101-0061, Japan.
  • Katayama M; Department of Neurosurgery, Tokyo Dental College, Ichikawa General Hospital, 5-11-13, Sugano, Ichikawa 272-8513, Japan.
  • Sakai K; Department of Oral Medicine and Hospital Dentistry, Tokyo Dental College, 5-11-13, Sugano, Ichikawa 272-8513, Japan.
  • Sato M; Laboratory of Biology, Tokyo Dental College, 2-9-18, Kandamisaki-cho, Chiyoda-ku, Tokyo 101-0061, Japan.
  • Abe S; Department of Anatomy, Tokyo Dental College, 2-9-18, Kandamisaki-cho, Chiyoda-ku, Tokyo 101-0061, Japan.
Int J Mol Sci ; 23(6)2022 Mar 10.
Article in En | MEDLINE | ID: mdl-35328407
ABSTRACT
Oral and perioral soft tissues cooperate with other oral and pharyngeal organs to facilitate mastication and swallowing. It is essential for these tissues to maintain their morphology for efficient function. Recently, it was reported that the morphology of oral and perioral soft tissue can be altered by aging or orthodontic treatment. However, it remains unclear whether tooth loss can alter these tissues' morphology. This study examined whether tooth loss could alter lip morphology. First, an analysis of human anatomy suggested that tooth loss altered lip morphology. Next, a murine model of tooth loss was established by extracting an incisor; micro-computed tomography revealed that a new bone replaced the extraction socket. Body weight was significantly lower in the tooth loss (UH) group than in the non-extraction control (NH) group. The upper lip showed a greater degree of morphological variation in the UH group. Proteomic analysis and immunohistochemical staining of the upper lip illustrated that S100A8/9 expression was higher in the UH group, suggesting that tooth loss induced lip inflammation. Finally, soft-diet feeding improved lip deformity associated with tooth loss, but not inflammation. Therefore, soft-diet feeding is essential for preventing lip morphological changes after tooth loss.
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Full text: 1 Database: MEDLINE Main subject: Tooth Loss / Incisor Limits: Animals Language: En Year: 2022 Type: Article

Full text: 1 Database: MEDLINE Main subject: Tooth Loss / Incisor Limits: Animals Language: En Year: 2022 Type: Article