Pioglitazone Synthetic Analogue Ameliorates Streptozotocin-Induced Diabetes Mellitus through Modulation of ACE 2/Angiotensin 1-7 via PI3K/AKT/mTOR Signaling Pathway.

Ahmed, Yasmin M; Abdelgawad, Mohamed A; Shalaby, Khaled; Ghoneim, Mohammed M; AboulMagd, Asmaa M; Abdelwahab, Nada S; Hassan, Hossam M; Othman, Asmaa M

Ahmed, Yasmin M; Abdelgawad, Mohamed A; Shalaby, Khaled; Ghoneim, Mohammed M; AboulMagd, Asmaa M; Abdelwahab, Nada S; Hassan, Hossam M; Othman, Asmaa M.

Affiliation

Ahmed YM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Nahda University, Beni-Suef 62514, Egypt.
Abdelgawad MA; Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka 72341, Al Jouf, Saudi Arabia.
Shalaby K; Department of Pharmaceutics, College of Pharmacy, Jouf University, Sakaka 72341, Al Jouf, Saudi Arabia.
Ghoneim MM; Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Ad Diriyah 13713, Saudi Arabia.
AboulMagd AM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Nahda University, Beni-Suef 62514, Egypt.
Abdelwahab NS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Nahda University, Beni-Suef 62514, Egypt.
Hassan HM; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62521, Egypt.
Othman AM; Department of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62521, Egypt.

Pharmaceuticals (Basel) ; 15(3)2022 Mar 10.

Article in En | MEDLINE | ID: mdl-35337139

Key words

angiotensin 17; angiotensin-converting enzyme 2 (ACE 2); insulin sensitivity; liver; phosphoinositide 3-kinases (PI3k); serein/threonine kinase (AKT); type 2 diabetes mellitus

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