Implications for herbal polypharmacy: coumarin-induced hepatotoxicity increased through common herbal phytochemicals astragaloside IV and atractylenolide I.

Britza, Susan M; Musgrave, Ian F; Byard, Roger W

Britza, Susan M; Musgrave, Ian F; Byard, Roger W.

Affiliation

Britza SM; School of Biomedicine, The University of Adelaide, Adelaide, Australia.
Musgrave IF; School of Biomedicine, The University of Adelaide, Adelaide, Australia.
Byard RW; School of Biomedicine, The University of Adelaide, Adelaide, Australia.

Toxicol Mech Methods ; 32(8): 606-615, 2022 Oct.

Article in En | MEDLINE | ID: mdl-35354423

Subject(s)

Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury/etiology; Chemical and Drug Induced Liver Injury/prevention & control; Coumarins/toxicity; Cytochrome P-450 Enzyme System/metabolism; Herb-Drug Interactions; Humans; Lactones; Phytochemicals; Polypharmacy; Rifampin; Saponins; Sesquiterpenes; Triterpenes

Key words

Coumarin; hepatotoxicity; herb toxicity; herbherb interactions; polyherbacy

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Full text: 1 Database: MEDLINE Main subject: Chemical and Drug Induced Liver Injury Type of study: Etiology_studies Limits: Humans Language: En Year: 2022 Type: Article

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