Circulating tumor DNA as a prognostic indicator of colorectal cancer recurrence-a systematic review and meta-analysis.
Int J Colorectal Dis
; 37(5): 1021-1027, 2022 May.
Article
in En
| MEDLINE
| ID: mdl-35384496
ABSTRACT
PURPOSE:
Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. After resection, patients need extensive follow-up to detect asymptomatic recurrences as early as possible to obtain optimal treatment. This study evaluated the prognostic value of circulating tumor DNA (ctDNA) for CRC recurrence.METHODS:
Two investigators independently conducted a systematic literature search of peer-reviewed studies that investigated the prognostic value of ctDNA in CRC. Fixed effects or random effects models were applied for all analyses based on the assessment of heterogeneity.RESULTS:
A total of 189 studies were initially retrieved from all databases; ultimately, eight studies with 879 CRC patients were included in this analysis. The pooled median recurrence-free survival was 11.36 months for ctDNA-positive patients. Meta-analysis of hazard ratio (HR) suggested that postoperative ctDNA-positive patients were more likely to experience cancer recurrence than ctDNA-negative patients (pooled HR 5.41; 95% confidence interval (CI) 2.37-8.45).CONCLUSIONS:
Successive monitoring of ctDNA status and follow-up with postoperative computed tomography (CT)/magnetic resonance imaging (MRI) are useful tools to detect early recurrence in postoperative ctDNA-positive patients.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Colorectal Neoplasms
/
Circulating Tumor DNA
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Systematic_reviews
Limits:
Humans
Language:
En
Year:
2022
Type:
Article