p63 in corneal and epidermal differentiation.
Biochem Biophys Res Commun
; 610: 15-22, 2022 06 25.
Article
in En
| MEDLINE
| ID: mdl-35430447
ABSTRACT
The transcription factor p63, belonging to the p53 family, is considered the master regulator of epidermal differentiation, skin, and in general of the differentiation of ectodermal tissues. Mutations in TP63 gene cause several rare ectodermal dysplasia disorders that refers to epidermal structural abnormalities and ocular surface disease, such as Ectrodactyly Ectodermal Dysplasia Clefting (EEC) syndrome. In this review, we discuss the key roles of p63 in keratinocytes and corneal epithelial differentiation, highlighting the function of the ΔNp63α isoform in driving limbal stem cell and epithelial stem cells commitment. We have summarized the specific ocular phenotypes observed in the TP63-mutation derived EEC syndrome, discussing the current and novel therapeutic strategies for the management of the ocular manifestations in EEC syndrome.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Ectodermal Dysplasia
/
Cleft Lip
/
Cleft Palate
Limits:
Humans
Language:
En
Year:
2022
Type:
Article