Improved prediction of radiation pneumonitis by combining biological and radiobiological parameters using a data-driven Bayesian network analysis.

Hinton, Tonaye; Karnak, David; Tang, Ming; Jiang, Ralph; Luo, Yi; Boonstra, Philip; Sun, Yilun; Nancarrow, Derek J; Sandford, Erin; Ray, Paramita; Maurino, Christopher; Matuszak, Martha; Schipper, Matthew J; Green, Michael D; Yanik, Gregory A; Tewari, Muneesh; Naqa, Issam El; Schonewolf, Caitlin A; Haken, Randall Ten; Jolly, Shruti; Lawrence, Theodore S; Ray, Dipankar

Hinton, Tonaye; Karnak, David; Tang, Ming; Jiang, Ralph; Luo, Yi; Boonstra, Philip; Sun, Yilun; Nancarrow, Derek J; Sandford, Erin; Ray, Paramita; Maurino, Christopher; Matuszak, Martha; Schipper, Matthew J; Green, Michael D; Yanik, Gregory A; Tewari, Muneesh; Naqa, Issam El; Schonewolf, Caitlin A; Haken, Randall Ten; Jolly, Shruti; Lawrence, Theodore S; Ray, Dipankar.

Affiliation

Hinton T; Department of Radiation Oncology, Medical School, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI 48109-2026, USA.
Karnak D; Department of Radiation Oncology, Medical School, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI 48109-2026, USA.
Tang M; Department of Radiation Oncology, Medical School, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI 48109-2026, USA; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Jiang R; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Luo Y; Department of Radiation Oncology, Medical School, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI 48109-2026, USA.
Boonstra P; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Sun Y; Department of Radiation Oncology, Medical School, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI 48109-2026, USA; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Nancarrow DJ; Department of Surgery, Division of Hematology-Oncology, Department of Internal Medicine, Medical School, University of Michigan, Ann Arbor, MI, USA.
Sandford E; Division of Hematology and Oncology, Department of Internal Medicine, Henry Ford Cancer Institute/Henry Ford Hospital, Detroit, MI, USA.
Ray P; Department of Radiation Oncology, Medical School, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI 48109-2026, USA.
Maurino C; Department of Radiation Oncology, Medical School, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI 48109-2026, USA.
Matuszak M; Department of Radiation Oncology, Medical School, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI 48109-2026, USA.
Schipper MJ; Department of Radiation Oncology, Medical School, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI 48109-2026, USA; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Green MD; Department of Radiation Oncology, Medical School, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI 48109-2026, USA.
Yanik GA; Division of Hematology and Oncology, Department of Internal Medicine, Henry Ford Cancer Institute/Henry Ford Hospital, Detroit, MI, USA.
Tewari M; Division of Hematology and Oncology, Department of Internal Medicine, Henry Ford Cancer Institute/Henry Ford Hospital, Detroit, MI, USA.
Naqa IE; Department of Radiation Oncology, Medical School, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI 48109-2026, USA.
Schonewolf CA; Department of Radiation Oncology, Medical School, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI 48109-2026, USA.
Haken RT; Department of Radiation Oncology, Medical School, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI 48109-2026, USA.
Jolly S; Department of Radiation Oncology, Medical School, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI 48109-2026, USA.
Lawrence TS; Department of Radiation Oncology, Medical School, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI 48109-2026, USA.
Ray D; Department of Radiation Oncology, Medical School, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI 48109-2026, USA. Electronic address: dipray@umich.edu.

Transl Oncol ; 21: 101428, 2022 Jul.

Article in En | MEDLINE | ID: mdl-35460942

Key words

Data-driven Bayesian network (DD-BN) analysis; Inflammatory cytokines; MicroRNA (miRNA); Radiation pneumonitis; Tumor necrosis factor alpha (TNFα) signaling, nuclear factor kappa B (NFκB)

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