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Understanding Interindividual Variability in the Drug Interaction of a Highly Extracted CYP1A2 Substrate Tizanidine: Application of a Permeability-Limited Multicompartment Liver Model in a Population Based Physiologically Based Pharmacokinetic Framework.
Zhang, Mian; Fisher, Ciarán; Gardner, Iain; Pan, Xian; Kilford, Peter; Bois, Frederic Y; Jamei, Masoud.
Affiliation
  • Zhang M; Certara UK Ltd, Simcyp Division, Level 2-Acero, Sheffield, United Kingdom.
  • Fisher C; Certara UK Ltd, Simcyp Division, Level 2-Acero, Sheffield, United Kingdom.
  • Gardner I; Certara UK Ltd, Simcyp Division, Level 2-Acero, Sheffield, United Kingdom.
  • Pan X; Certara UK Ltd, Simcyp Division, Level 2-Acero, Sheffield, United Kingdom.
  • Kilford P; Certara UK Ltd, Simcyp Division, Level 2-Acero, Sheffield, United Kingdom.
  • Bois FY; Certara UK Ltd, Simcyp Division, Level 2-Acero, Sheffield, United Kingdom.
  • Jamei M; Certara UK Ltd, Simcyp Division, Level 2-Acero, Sheffield, United Kingdom masoud.jamei@certara.com.
Drug Metab Dispos ; 50(7): 957-967, 2022 07.
Article in En | MEDLINE | ID: mdl-35504655
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Full text: 1 Database: MEDLINE Main subject: Cytochrome P-450 CYP1A2 / Cytochrome P-450 CYP1A2 Inhibitors Type of study: Prognostic_studies Limits: Humans Language: En Year: 2022 Type: Article
Fulltext
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PubMed Links
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Full text: 1 Database: MEDLINE Main subject: Cytochrome P-450 CYP1A2 / Cytochrome P-450 CYP1A2 Inhibitors Type of study: Prognostic_studies Limits: Humans Language: En Year: 2022 Type: Article