Hydrostatic pressure as a driver of cell and tissue morphogenesis.
Semin Cell Dev Biol
; 131: 134-145, 2022 11.
Article
in En
| MEDLINE
| ID: mdl-35534334
ABSTRACT
Morphogenesis, the process by which tissues develop into functional shapes, requires coordinated mechanical forces. Most current literature ascribes contractile forces derived from actomyosin networks as the major driver of tissue morphogenesis. Recent works from diverse species have shown that pressure derived from fluids can generate deformations necessary for tissue morphogenesis. In this review, we discuss how hydrostatic pressure is generated at the cellular and tissue level and how the pressure can cause deformations. We highlight and review findings demonstrating the mechanical roles of pressures from fluid-filled lumens and viscous gel-like components of the extracellular matrix. We also emphasise the interactions and mechanochemical feedbacks between extracellular pressures and tissue behaviour in driving tissue remodelling. Lastly, we offer perspectives on the open questions in the field that will further our understanding to uncover new principles of tissue organisation during development.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Actomyosin
Language:
En
Year:
2022
Type:
Article