Isomeric lipid signatures reveal compartmentalized fatty acid metabolism in cancer.

Young, Reuben S E; Bowman, Andrew P; Tousignant, Kaylyn D; Poad, Berwyck L J; Gunter, Jennifer H; Philp, Lisa K; Nelson, Colleen C; Ellis, Shane R; Heeren, Ron M A; Sadowski, Martin C; Blanksby, Stephen J

Young, Reuben S E; Bowman, Andrew P; Tousignant, Kaylyn D; Poad, Berwyck L J; Gunter, Jennifer H; Philp, Lisa K; Nelson, Colleen C; Ellis, Shane R; Heeren, Ron M A; Sadowski, Martin C; Blanksby, Stephen J.

Affiliation

Young RSE; School of Chemistry and Physics, Queensland University of Technology, Brisbane, Queensland, Australia; Central Analytical Research Facility (CARF), Queensland University of Technology, Brisbane, Queensland, Australia.
Bowman AP; The Maastricht MultiModal Molecular Imaging Institute (M4I), Division of Imaging Mass Spectrometry, Maastricht University, Maastricht, The Netherlands.
Tousignant KD; Australian Prostate Cancer Research Centre - Queensland (APCRC-Q), School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute (TRI), Brisbane, Queensland, Australia.
Poad BLJ; School of Chemistry and Physics, Queensland University of Technology, Brisbane, Queensland, Australia; Central Analytical Research Facility (CARF), Queensland University of Technology, Brisbane, Queensland, Australia.
Gunter JH; Australian Prostate Cancer Research Centre - Queensland (APCRC-Q), School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute (TRI), Brisbane, Queensland, Australia.
Philp LK; Australian Prostate Cancer Research Centre - Queensland (APCRC-Q), School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute (TRI), Brisbane, Queensland, Australia.
Nelson CC; Australian Prostate Cancer Research Centre - Queensland (APCRC-Q), School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute (TRI), Brisbane, Queensland, Australia.
Ellis SR; The Maastricht MultiModal Molecular Imaging Institute (M4I), Division of Imaging Mass Spectrometry, Maastricht University, Maastricht, The Netherlands; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, New South Wales, Australia; Illawarra Hea
Heeren RMA; The Maastricht MultiModal Molecular Imaging Institute (M4I), Division of Imaging Mass Spectrometry, Maastricht University, Maastricht, The Netherlands.
Sadowski MC; Australian Prostate Cancer Research Centre - Queensland (APCRC-Q), School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute (TRI), Brisbane, Queensland, Australia; Institute of Pathology, University of Bern,
Blanksby SJ; School of Chemistry and Physics, Queensland University of Technology, Brisbane, Queensland, Australia; Central Analytical Research Facility (CARF), Queensland University of Technology, Brisbane, Queensland, Australia. Electronic address: stephen.blanksby@qut.edu.au.

J Lipid Res ; 63(6): 100223, 2022 06.

Article in En | MEDLINE | ID: mdl-35537528

Subject(s)

Fatty Acids; Neoplasms; Fatty Acids/metabolism; Glycerophospholipids/chemistry; Lipid Metabolism; Signal Transduction

Key words

FA/transport; imaging MS; lipase; lipid isomers; lipolysis and FA metabolism; ozone-induced dissociation; phospholipid/metabolism; phospholipids/phosphatidylcholine; stable-isotope tracing

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