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Single-cell eQTL models reveal dynamic T cell state dependence of disease loci.
Nathan, Aparna; Asgari, Samira; Ishigaki, Kazuyoshi; Valencia, Cristian; Amariuta, Tiffany; Luo, Yang; Beynor, Jessica I; Baglaenko, Yuriy; Suliman, Sara; Price, Alkes L; Lecca, Leonid; Murray, Megan B; Moody, D Branch; Raychaudhuri, Soumya.
Affiliation
  • Nathan A; Center for Data Sciences, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Asgari S; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Ishigaki K; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Valencia C; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Amariuta T; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
  • Luo Y; Center for Data Sciences, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Beynor JI; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Baglaenko Y; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Suliman S; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Price AL; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
  • Lecca L; Center for Data Sciences, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Murray MB; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Moody DB; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Raychaudhuri S; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Nature ; 606(7912): 120-128, 2022 06.
Article in En | MEDLINE | ID: mdl-35545678
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Full text: 1 Database: MEDLINE Main subject: Genetic Predisposition to Disease / Quantitative Trait Loci / Memory T Cells Type of study: Prognostic_studies Limits: Humans Country/Region as subject: America do sul / Peru Language: En Year: 2022 Type: Article
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PubMed Links
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Full text: 1 Database: MEDLINE Main subject: Genetic Predisposition to Disease / Quantitative Trait Loci / Memory T Cells Type of study: Prognostic_studies Limits: Humans Country/Region as subject: America do sul / Peru Language: En Year: 2022 Type: Article