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The mystery of the life tree: the placentas†.
Shao, Xuan; Yu, Wenzhe; Yang, Yun; Wang, Feiyang; Yu, Xin; Wu, Hongyu; Ma, Yeling; Cao, Bin; Wang, Yan-Ling.
Affiliation
  • Shao X; State Key Laboratory of Stem cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
  • Yu W; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.
  • Yang Y; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China.
  • Wang F; University of the Chinese Academy of Sciences, Beijing, China.
  • Yu X; Department of Obstetrics and Gynecology, Fujian Provincial Key Laboratory of Reproductive Health Research, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China.
  • Wu H; State Key Laboratory of Stem cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
  • Ma Y; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.
  • Cao B; University of the Chinese Academy of Sciences, Beijing, China.
  • Wang YL; State Key Laboratory of Stem cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Biol Reprod ; 107(1): 301-316, 2022 07 25.
Article in En | MEDLINE | ID: mdl-35552600
The placenta is the interface between the fetal and maternal environments during mammalian gestation, critically safeguarding the health of the developing fetus and the mother. Placental trophoblasts origin from embryonic trophectoderm that differentiates into various trophoblastic subtypes through villous and extravillous pathways. The trophoblasts actively interact with multiple decidual cells and immune cells at the maternal-fetal interface and thus construct fundamental functional units, which are responsible for blood perfusion, maternal-fetal material exchange, placental endocrine, immune tolerance, and adequate defense barrier against pathogen infection. Various pregnant complications are tightly associated with the defects in placental development and function maintenance. In this review, we summarize the current views and our recent progress on the mechanisms underlying the formation of placental functional units, the interactions among trophoblasts and various uterine cells, as well as the placental barrier against pathogen infections during pregnancy. The involvement of placental dysregulation in adverse pregnancy outcomes is discussed.
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Full text: 1 Database: MEDLINE Main subject: Placenta Limits: Animals / Pregnancy Language: En Year: 2022 Type: Article

Full text: 1 Database: MEDLINE Main subject: Placenta Limits: Animals / Pregnancy Language: En Year: 2022 Type: Article