Actual Associations between HLA Haplotype and Graves' Disease Development.
J Clin Med
; 11(9)2022 Apr 29.
Article
in En
| MEDLINE
| ID: mdl-35566618
ABSTRACT
The association between HLA and the risk of Graves' disease (GD) has been analyzed for many years. However, the results were often inconsistent and mostly regarded Asian populations. The purpose of our study was to perform HLA genotyping using a next-generation sequencing (NGS) method in Caucasians, to find out which alleles are eventually correlated with GD morbidity as well as which of them can be considered protective. HLA-A, -B, -C, -DQB1, -DRB1 were genotyped using a next-generation sequencing method in 2376 persons, including 159 GD patients and 2217 healthy controls. We have demonstrated a significant association between the risk of GD and the following alleles HLA-B*0801, -B*3906, -B*3701, -C*0701, -C*1402, -C*0302, -C*1701, -DRB1*0301, -DRB1*1101, -DRB1*1303, -DRB1*0103, -DRB1*1401, -DQB1*0301, DQB1*0201. The alleles HLA-B*3906, -B*3701, -C*1402, -C*0302, -C*1701, -DRB1*1401 are novel GD-associated, previously not-reported independent ones with no linkage disequilibrium with other high-risk alleles. On the other hand, the frequencies of HLA-B*0702, -C*0702, -C*0304, DRB1*0701, -DQB1*0202, -DQB1*0303 were significantly lower in GD compared to controls. This study demonstrated the actual relationships between HLA and GD based on the NGS method and provided a novel set of alleles as a reliable tool for an individual personalized risk assessment.
Full text:
1
Database:
MEDLINE
Type of study:
Risk_factors_studies
Language:
En
Year:
2022
Type:
Article