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Structural and dynamic determinants for highly selective RET kinase inhibition reveal cryptic druggability.
Shehata, Moustafa A; Contreras, Julia; Martín-Hurtado, Ana; Froux, Aurane; Mohamed, Hossam Taha; El-Sherif, Ahmed A; Plaza-Menacho, Iván.
Affiliation
  • Shehata MA; Kinases, Protein Phosphorylation and Cancer Group, Structural Biology Programme, Spanish National Cancer Research Center (CNIO), Madrid 28029, Spain; Chemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt.
  • Contreras J; Kinases, Protein Phosphorylation and Cancer Group, Structural Biology Programme, Spanish National Cancer Research Center (CNIO), Madrid 28029, Spain.
  • Martín-Hurtado A; Kinases, Protein Phosphorylation and Cancer Group, Structural Biology Programme, Spanish National Cancer Research Center (CNIO), Madrid 28029, Spain.
  • Froux A; Kinases, Protein Phosphorylation and Cancer Group, Structural Biology Programme, Spanish National Cancer Research Center (CNIO), Madrid 28029, Spain.
  • Mohamed HT; Zoology Department, Faculty of Science, Cairo University, Giza 12613, Egypt; Faculty of Biotechnology, October University for Modern Sciences and Arts, Giza 12451, Egypt.
  • El-Sherif AA; Chemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt.
  • Plaza-Menacho I; Kinases, Protein Phosphorylation and Cancer Group, Structural Biology Programme, Spanish National Cancer Research Center (CNIO), Madrid 28029, Spain. Electronic address: iplaza@cnio.es.
J Adv Res ; 45: 87-100, 2023 03.
Article in En | MEDLINE | ID: mdl-35595215
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Full text: 1 Database: MEDLINE Main subject: Proto-Oncogene Proteins c-ret / Neoplasms Limits: Humans Language: En Year: 2023 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Proto-Oncogene Proteins c-ret / Neoplasms Limits: Humans Language: En Year: 2023 Type: Article