Resveratrol mitigates diclofenac-induced hepatorenal toxicity in rats via modulation of miR-144/Nrf2/GSH axis.

Elbaz, Eman M; Ahmed, Kawkab A; Abdelmonem, Maha

Elbaz, Eman M; Ahmed, Kawkab A; Abdelmonem, Maha.

Affiliation

Elbaz EM; Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Ahmed KA; Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Cairo, Egypt.
Abdelmonem M; Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

J Biochem Mol Toxicol ; 36(9): e23129, 2022 Sep.

Article in En | MEDLINE | ID: mdl-35673973

Subject(s)

MicroRNAs; NF-E2-Related Factor 2; Animals; Antioxidants/therapeutic use; Biomarkers/metabolism; Caspase 3/metabolism; Diclofenac/toxicity; Glutathione/metabolism; Inflammation/pathology; MicroRNAs/genetics; MicroRNAs/metabolism; NF-E2-Related Factor 2/genetics; NF-E2-Related Factor 2/metabolism; NF-kappa B/metabolism; Oxidative Stress; Rats; Resveratrol/pharmacology; Tumor Necrosis Factor-alpha/metabolism

Key words

GSH; Nrf2; diclofenac; miR-144; resveratrol

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Full text: 1 Database: MEDLINE Main subject: MicroRNAs / NF-E2-Related Factor 2 Limits: Animals Language: En Year: 2022 Type: Article

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Full text: 1 Database: MEDLINE Main subject: MicroRNAs / NF-E2-Related Factor 2 Limits: Animals Language: En Year: 2022 Type: Article