Anti-Growth, Anti-Angiogenic, and Pro-Apoptotic Effects by CX-4945, an Inhibitor of Casein Kinase 2, on HuCCT-1 Human Cholangiocarcinoma Cells via Control of Caspase-9/3, DR-4, STAT-3/STAT-5, Mcl-1, eIF-2&#945;, and HIF-1&#945;.

Wang, Saini; Yadav, Anil Kumar; Han, Jin-Yi; Ahn, Keun Soo; Jang, Byeong-Churl

Anti-Growth, Anti-Angiogenic, and Pro-Apoptotic Effects by CX-4945, an Inhibitor of Casein Kinase 2, on HuCCT-1 Human Cholangiocarcinoma Cells via Control of Caspase-9/3, DR-4, STAT-3/STAT-5, Mcl-1, eIF-2α, and HIF-1α.

Wang, Saini; Yadav, Anil Kumar; Han, Jin-Yi; Ahn, Keun Soo; Jang, Byeong-Churl.

Affiliation

Wang S; Department of Molecular Medicine, College of Medicine, Keimyung University, 1095 Dalgubeoldaero, Dalseo-gu, Daegu 42601, Korea.
Yadav AK; Department of Surgery, Keimyung University Dongsan Hospital, 1035 Dalgubeol-daero, Dalseo-gu, Daegu 41931, Korea.
Han JY; Department of Molecular Medicine, College of Medicine, Keimyung University, 1095 Dalgubeoldaero, Dalseo-gu, Daegu 42601, Korea.
Ahn KS; The Hormel Institute, University of Minnesota, Austin, MN 55812, USA.
Jang BC; Department of Surgery, Keimyung University Dongsan Hospital, 1035 Dalgubeol-daero, Dalseo-gu, Daegu 41931, Korea.

Int J Mol Sci ; 23(11)2022 Jun 06.

Article in En | MEDLINE | ID: mdl-35683032

Subject(s)

Bile Duct Neoplasms; Cholangiocarcinoma; Bile Duct Neoplasms/drug therapy; Bile Ducts, Intrahepatic; Casein Kinase II/genetics; Caspase 9; Cell Line, Tumor; Cholangiocarcinoma/drug therapy; Eukaryotic Initiation Factor-2; Humans; Naphthyridines; Phenazines

Key words

CK2; CX-4945; HIF-1α; HuCCT-1; Mcl-1; STAT-3

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Full text: 1 Database: MEDLINE Main subject: Bile Duct Neoplasms / Cholangiocarcinoma Limits: Humans Language: En Year: 2022 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Bile Duct Neoplasms / Cholangiocarcinoma Limits: Humans Language: En Year: 2022 Type: Article