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Metabolic-scale gene activation screens identify SLCO2B1 as a heme transporter that enhances cellular iron availability.
Unlu, Gokhan; Prizer, Benjamin; Erdal, Ranya; Yeh, Hsi-Wen; Bayraktar, Erol C; Birsoy, Kivanç.
Affiliation
  • Unlu G; Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY 10065, USA.
  • Prizer B; Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY 10065, USA.
  • Erdal R; Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY 10065, USA; Medical Scientist Training Program, Hacettepe University Faculty of Medicine, Ankara 06230, Turkey.
  • Yeh HW; Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY 10065, USA.
  • Bayraktar EC; Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY 10065, USA.
  • Birsoy K; Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY 10065, USA. Electronic address: kbirsoy@rockefeller.edu.
Mol Cell ; 82(15): 2832-2843.e7, 2022 08 04.
Article in En | MEDLINE | ID: mdl-35714613
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Full text: 1 Database: MEDLINE Main subject: Organic Anion Transporters / Heme / Iron Limits: Animals Language: En Year: 2022 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Organic Anion Transporters / Heme / Iron Limits: Animals Language: En Year: 2022 Type: Article