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Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis.
He, Dan; Feng, Huijin; Sundberg, Belen; Yang, Jiaxing; Powers, Justin; Christian, Alec H; Wilkinson, John E; Monnin, Cian; Avizonis, Daina; Thomas, Craig J; Friedman, Richard A; Kluger, Michael D; Hollingsworth, Michael A; Grandgenett, Paul M; Klute, Kelsey A; Toste, F Dean; Chang, Christopher J; Chio, Iok In Christine.
Affiliation
  • He D; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
  • Feng H; Institute for Cancer Genetics, Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA.
  • Sundberg B; Institute for Cancer Genetics, Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA.
  • Yang J; Institute for Cancer Genetics, Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA.
  • Powers J; Institute for Cancer Genetics, Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA.
  • Christian AH; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
  • Wilkinson JE; University of Michigan Medical School, Ann Arbor, MI 48109, USA.
  • Monnin C; Metabolomics Innovation Resource, Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC H3A 1A3, Canada.
  • Avizonis D; Metabolomics Innovation Resource, Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC H3A 1A3, Canada.
  • Thomas CJ; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA; Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Friedman RA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Biomedical Informatics, Columbia University Irving Medical Center, New York, NY 10032, USA.
  • Kluger MD; Division of Gastrointestinal & Endocrine Surgery, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
  • Hollingsworth MA; Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.
  • Grandgenett PM; Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.
  • Klute KA; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.
  • Toste FD; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
  • Chang CJ; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: chrischang@berkeley.edu.
  • Chio IIC; Institute for Cancer Genetics, Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address: christine.chio@columbia.edu.
Mol Cell ; 82(16): 3045-3060.e11, 2022 08 18.
Article in En | MEDLINE | ID: mdl-35752173
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Full text: 1 Database: MEDLINE Main subject: Pancreatic Neoplasms / Thyroid Hormones / Carrier Proteins / Carcinoma, Pancreatic Ductal / Membrane Proteins Limits: Humans Language: En Year: 2022 Type: Article
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Pancreatic Neoplasms / Thyroid Hormones / Carrier Proteins / Carcinoma, Pancreatic Ductal / Membrane Proteins Limits: Humans Language: En Year: 2022 Type: Article