Silencing of the Ca<sup>2+</sup> Channel ORAI1 Improves the Multi-Systemic Phenotype of Tubular Aggregate Myopathy (TAM) and Stormorken Syndrome (STRMK) in Mice.

Silva-Rojas, Roberto; Pérez-Guàrdia, Laura; Lafabrie, Emma; Moulaert, David; Laporte, Jocelyn; Böhm, Johann

Silencing of the Ca²⁺ Channel ORAI1 Improves the Multi-Systemic Phenotype of Tubular Aggregate Myopathy (TAM) and Stormorken Syndrome (STRMK) in Mice.

Silva-Rojas, Roberto; Pérez-Guàrdia, Laura; Lafabrie, Emma; Moulaert, David; Laporte, Jocelyn; Böhm, Johann.

Affiliation

Silva-Rojas R; IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire), Inserm U1258, CNRS UMR7104, Université de Strasbourg, 67404 Illkirch, France.
Pérez-Guàrdia L; IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire), Inserm U1258, CNRS UMR7104, Université de Strasbourg, 67404 Illkirch, France.
Lafabrie E; IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire), Inserm U1258, CNRS UMR7104, Université de Strasbourg, 67404 Illkirch, France.
Moulaert D; Institut Clinique de la Souris (ICS), 67404 Illkirch, France.
Laporte J; IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire), Inserm U1258, CNRS UMR7104, Université de Strasbourg, 67404 Illkirch, France.
Böhm J; IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire), Inserm U1258, CNRS UMR7104, Université de Strasbourg, 67404 Illkirch, France.

Int J Mol Sci ; 23(13)2022 Jun 23.

Article in En | MEDLINE | ID: mdl-35805973

Subject(s)

Blood Platelet Disorders; Dyslexia; Ichthyosis; Myopathies, Structural, Congenital; ORAI1 Protein; Animals; Blood Platelet Disorders/genetics; Blood Platelet Disorders/metabolism; Calcium/metabolism; Dyslexia/genetics; Dyslexia/metabolism; Erythrocytes, Abnormal; Ichthyosis/genetics; Ichthyosis/metabolism; Mice; Migraine Disorders/genetics; Migraine Disorders/metabolism; Miosis; Muscle Fatigue; Myopathies, Structural, Congenital/genetics; Myopathies, Structural, Congenital/metabolism; Myopathies, Structural, Congenital/pathology; ORAI1 Protein/genetics; ORAI1 Protein/metabolism; Phenotype; Spleen/abnormalities; Spleen/metabolism; Stromal Interaction Molecule 1/genetics; Stromal Interaction Molecule 1/metabolism

Key words

ORAI1; STIM1; Stormorken syndrome; calcium; ion channel; mouse model; muscle disorder; shRNA; tubular aggregate myopathy

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Full text: 1 Database: MEDLINE Main subject: Blood Platelet Disorders / Myopathies, Structural, Congenital / Dyslexia / ORAI1 Protein / Ichthyosis Type of study: Prognostic_studies Limits: Animals Language: En Year: 2022 Type: Article

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