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SIRT1 pharmacological activation rescues vascular dysfunction and prevents thrombosis in MTHFR deficiency.
Carrizzo, Albino; Iside, Concetta; Nebbioso, Angela; Carafa, Vincenzo; Damato, Antonio; Sciarretta, Sebastiano; Frati, Giacomo; Di Nonno, Flavio; Valenti, Valentina; Ciccarelli, Michele; Venturini, Eleonora; Scioli, Mariarosaria; Di Pietro, Paola; Bucci, Tommaso; Giudice, Valentina; Storto, Marianna; Serio, Bianca; Puca, Annibale Alessandro; Giugliano, Giuseppe; Trimarco, Valentina; Izzo, Raffaele; Trimarco, Bruno; Selleri, Carmine; Altucci, Lucia; Vecchione, Carmine.
Affiliation
  • Carrizzo A; Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana" University of Salerno, Via S. Allende, 84081, Baronissi, Italy.
  • Iside C; IRCCS Neuromed, Vascular Physiopathology Unit, 86077, Pozzilli, Italy.
  • Nebbioso A; IRCCS Synlab SDN, Via E. Gianturco 113, 80143, Naples, Italy.
  • Carafa V; Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Vico L. De Crecchio, 80138, Naples, Italy.
  • Damato A; Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Vico L. De Crecchio, 80138, Naples, Italy.
  • Sciarretta S; IRCCS Neuromed, Vascular Physiopathology Unit, 86077, Pozzilli, Italy.
  • Frati G; IRCCS Neuromed, Vascular Physiopathology Unit, 86077, Pozzilli, Italy.
  • Di Nonno F; Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100, Latina, Italy.
  • Valenti V; IRCCS Neuromed, Vascular Physiopathology Unit, 86077, Pozzilli, Italy.
  • Ciccarelli M; Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100, Latina, Italy.
  • Venturini E; IRCCS Neuromed, Vascular Physiopathology Unit, 86077, Pozzilli, Italy.
  • Scioli M; Department of Cardiology, Santa Maria Goretti Hospital, 04100, Latina, Italy.
  • Di Pietro P; Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana" University of Salerno, Via S. Allende, 84081, Baronissi, Italy.
  • Bucci T; IRCCS Neuromed, Vascular Physiopathology Unit, 86077, Pozzilli, Italy.
  • Giudice V; IRCCS Neuromed, Vascular Physiopathology Unit, 86077, Pozzilli, Italy.
  • Storto M; Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana" University of Salerno, Via S. Allende, 84081, Baronissi, Italy.
  • Serio B; Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana" University of Salerno, Via S. Allende, 84081, Baronissi, Italy.
  • Puca AA; Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana" University of Salerno, Via S. Allende, 84081, Baronissi, Italy.
  • Giugliano G; Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana" University of Salerno, Via S. Allende, 84081, Baronissi, Italy.
  • Trimarco V; University Hospital, San Giovanni di Dio e Ruggi D'Aragona, 84125, Salerno, Italy.
  • Izzo R; Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana" University of Salerno, Via S. Allende, 84081, Baronissi, Italy.
  • Trimarco B; IRCCS Multimedica, Ageing Unit, Via G. Fantoli 16/15, 20138, Milan, Italy.
  • Selleri C; Department of Advanced Biomedical Sciences, "Federico II" University, Via Pansini 5, 80131, Naples, Italy.
  • Altucci L; Department of Neuroscience, Reproductive Sciences and Dentistry, "Federico II" University, Via Pansini 5, 80131, Naples, Italy.
  • Vecchione C; Department of Advanced Biomedical Sciences, "Federico II" University, Via Pansini 5, 80131, Naples, Italy.
Cell Mol Life Sci ; 79(8): 410, 2022 Jul 11.
Article in En | MEDLINE | ID: mdl-35821533
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Full text: 1 Database: MEDLINE Main subject: Thrombosis / Methylenetetrahydrofolate Reductase (NADPH2) / Sirtuin 1 / Homocystinuria Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Year: 2022 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Thrombosis / Methylenetetrahydrofolate Reductase (NADPH2) / Sirtuin 1 / Homocystinuria Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Year: 2022 Type: Article