Preclinical Evaluation of Recombinant Microbial Glycoside Hydrolases as Antibiofilm Agents in Acute Pulmonary Pseudomonas aeruginosa Infection.

Ostapska, Hanna; Raju, Deepa; Corsini, Rachel; Lehoux, Melanie; Lacdao, Ira; Gilbert, Stephanie; Sivarajah, Piyanka; Bamford, Natalie C; Baker, Perrin; Gravelat, Fabrice N; Howell, P Lynne; Sheppard, Donald C

Ostapska, Hanna; Raju, Deepa; Corsini, Rachel; Lehoux, Melanie; Lacdao, Ira; Gilbert, Stephanie; Sivarajah, Piyanka; Bamford, Natalie C; Baker, Perrin; Gravelat, Fabrice N; Howell, P Lynne; Sheppard, Donald C.

Affiliation

Ostapska H; Department of Microbiology and Immunology, McGill Universitygrid.14709.3bgrid.63984.30, Montreal, Quebec, Canada.
Raju D; Infectious Disease and Immunity in Global Health Program, McGill Universitygrid.14709.3bgrid.63984.30 Health Centre, Montreal, Quebec, Canada.
Corsini R; Program in Molecular Medicine, Research Institute, The Hospital for Sick Childrengrid.42327.30, Toronto, Ontario, Canada.
Lehoux M; Department of Microbiology and Immunology, McGill Universitygrid.14709.3bgrid.63984.30, Montreal, Quebec, Canada.
Lacdao I; Infectious Disease and Immunity in Global Health Program, McGill Universitygrid.14709.3bgrid.63984.30 Health Centre, Montreal, Quebec, Canada.
Gilbert S; Department of Microbiology and Immunology, McGill Universitygrid.14709.3bgrid.63984.30, Montreal, Quebec, Canada.
Sivarajah P; Infectious Disease and Immunity in Global Health Program, McGill Universitygrid.14709.3bgrid.63984.30 Health Centre, Montreal, Quebec, Canada.
Bamford NC; Infectious Disease and Immunity in Global Health Program, McGill Universitygrid.14709.3bgrid.63984.30 Health Centre, Montreal, Quebec, Canada.
Baker P; Program in Molecular Medicine, Research Institute, The Hospital for Sick Childrengrid.42327.30, Toronto, Ontario, Canada.
Gravelat FN; Program in Molecular Medicine, Research Institute, The Hospital for Sick Childrengrid.42327.30, Toronto, Ontario, Canada.
Howell PL; Program in Molecular Medicine, Research Institute, The Hospital for Sick Childrengrid.42327.30, Toronto, Ontario, Canada.
Sheppard DC; Program in Molecular Medicine, Research Institute, The Hospital for Sick Childrengrid.42327.30, Toronto, Ontario, Canada.

Antimicrob Agents Chemother ; 66(8): e0005222, 2022 08 16.

Article in En | MEDLINE | ID: mdl-35862738

Subject(s)

Pseudomonas Infections; Animals; Anti-Bacterial Agents/metabolism; Anti-Bacterial Agents/pharmacology; Anti-Bacterial Agents/therapeutic use; Biofilms; Glycoside Hydrolases/metabolism; Lung/metabolism; Mice; Polysaccharides, Bacterial/metabolism; Pseudomonas Infections/drug therapy; Pseudomonas Infections/microbiology; Pseudomonas aeruginosa/metabolism

Key words

Pel; Pseudomonas aeruginosa; Psl; acute pulmonary infection; antibiotic; antimicrobial combinations; bacteria; biofilm; exopolysaccharide; glycoside hydrolase (GH)

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