Digitoxin Affects Metabolism, ROS Production and Proliferation in Pancreatic Cancer Cells Differently Depending on the Cell Phenotype.

Lindholm, Heléne; Ejeskär, Katarina; Szekeres, Ferenc

Lindholm, Heléne; Ejeskär, Katarina; Szekeres, Ferenc.

Affiliation

Lindholm H; Biomedicine, School of Health Sciences, University of Skövde, 54145 Skövde, Sweden.
Ejeskär K; Biomedicine, School of Health Sciences, University of Skövde, 54145 Skövde, Sweden.
Szekeres F; Biomedicine, School of Health Sciences, University of Skövde, 54145 Skövde, Sweden.

Int J Mol Sci ; 23(15)2022 Jul 26.

Article in En | MEDLINE | ID: mdl-35897809

Subject(s)

Digitoxin; Pancreatic Neoplasms; Apoptosis; Cell Line, Tumor; Cell Proliferation; Digitoxin/pharmacology; Humans; Pancreatic Neoplasms/pathology; Phenotype; Proto-Oncogene Proteins p21(ras)/genetics; Proto-Oncogene Proteins p21(ras)/metabolism; Reactive Oxygen Species/metabolism; Pancreatic Neoplasms

Key words

KRAS; PDAC; ROS; cardiac glycosides; cell proliferation; digitoxin; metabolism; pancreatic cancer

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Full text: 1 Database: MEDLINE Main subject: Pancreatic Neoplasms / Digitoxin Limits: Humans Language: En Year: 2022 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Pancreatic Neoplasms / Digitoxin Limits: Humans Language: En Year: 2022 Type: Article