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Intratracheally administered LNA gapmer antisense oligonucleotides induce robust gene silencing in mouse lung fibroblasts.
Shin, Minwook; Chan, Io Long; Cao, Yuming; Gruntman, Alisha M; Lee, Jonathan; Sousa, Jacquelyn; Rodríguez, Tomás C; Echeverria, Dimas; Devi, Gitali; Debacker, Alexandre J; Moazami, Michael P; Krishnamurthy, Pranathi Meda; Rembetsy-Brown, Julia M; Kelly, Karen; Yukselen, Onur; Donnard, Elisa; Parsons, Teagan J; Khvorova, Anastasia; Sontheimer, Erik J; Maehr, René; Garber, Manuel; Watts, Jonathan K.
Affiliation
  • Shin M; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
  • Chan IL; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
  • Cao Y; Program in Bioinformatics and Integrative Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
  • Gruntman AM; Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
  • Lee J; Department of Pediatrics, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
  • Sousa J; Department of Clinical Sciences, Cummings School of Veterinary Medicine at Tufts University, N. Grafton, MA 01536, USA.
  • Rodríguez TC; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
  • Echeverria D; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
  • Devi G; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
  • Debacker AJ; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
  • Moazami MP; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
  • Krishnamurthy PM; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
  • Rembetsy-Brown JM; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
  • Kelly K; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
  • Yukselen O; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
  • Donnard E; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
  • Parsons TJ; Program in Bioinformatics and Integrative Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
  • Khvorova A; Program in Bioinformatics and Integrative Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
  • Sontheimer EJ; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
  • Maehr R; Diabetes Center of Excellence, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
  • Garber M; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
  • Watts JK; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Nucleic Acids Res ; 50(15): 8418-8430, 2022 08 26.
Article in En | MEDLINE | ID: mdl-35920332
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Full text: 1 Database: MEDLINE Main subject: Oligonucleotides, Antisense / Endothelial Cells / Fibroblasts / Lung Limits: Animals Language: En Year: 2022 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Oligonucleotides, Antisense / Endothelial Cells / Fibroblasts / Lung Limits: Animals Language: En Year: 2022 Type: Article