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Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies.
Reichart, Daniel; Lindberg, Eric L; Maatz, Henrike; Miranda, Antonio M A; Viveiros, Anissa; Shvetsov, Nikolay; Gärtner, Anna; Nadelmann, Emily R; Lee, Michael; Kanemaru, Kazumasa; Ruiz-Orera, Jorge; Strohmenger, Viktoria; DeLaughter, Daniel M; Patone, Giannino; Zhang, Hao; Woehler, Andrew; Lippert, Christoph; Kim, Yuri; Adami, Eleonora; Gorham, Joshua M; Barnett, Sam N; Brown, Kemar; Buchan, Rachel J; Chowdhury, Rasheda A; Constantinou, Chrystalla; Cranley, James; Felkin, Leanne E; Fox, Henrik; Ghauri, Ahla; Gummert, Jan; Kanda, Masatoshi; Li, Ruoyan; Mach, Lukas; McDonough, Barbara; Samari, Sara; Shahriaran, Farnoush; Yapp, Clarence; Stanasiuk, Caroline; Theotokis, Pantazis I; Theis, Fabian J; van den Bogaerdt, Antoon; Wakimoto, Hiroko; Ware, James S; Worth, Catherine L; Barton, Paul J R; Lee, Young-Ae; Teichmann, Sarah A; Milting, Hendrik; Noseda, Michela; Oudit, Gavin Y.
Affiliation
  • Reichart D; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
  • Lindberg EL; Cardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Maatz H; Department of Medicine I, University Hospital, LMU Munich, 80336 Munich, Germany.
  • Miranda AMA; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany.
  • Viveiros A; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany.
  • Shvetsov N; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, 10785 Berlin, Germany.
  • Gärtner A; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.
  • Nadelmann ER; British Heart Foundation Centre for Research Excellence and Centre for Regenerative Medicine, Imperial College London, London WC2R 2LS, UK.
  • Lee M; Division of Cardiology, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta T6G 2R3, Canada.
  • Kanemaru K; Mazankowski Alberta Heart Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta T6G 2R3, Canada.
  • Ruiz-Orera J; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany.
  • Strohmenger V; Erich and Hanna Klessmann Institute, Heart and Diabetes Center NRW, University Hospital of the Ruhr-University Bochum, 32545 Bad Oeynhausen, Germany.
  • DeLaughter DM; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
  • Patone G; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.
  • Zhang H; Cellular Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.
  • Woehler A; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany.
  • Lippert C; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
  • Kim Y; Walter-Brendel-Centre of Experimental Medicine, Ludwig-Maximilian University of Munich, 81377 Munich, Germany.
  • Adami E; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
  • Gorham JM; Howard Hughes Medical Institute, Bethesda, MD 20815, USA.
  • Barnett SN; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany.
  • Brown K; Division of Cardiology, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta T6G 2R3, Canada.
  • Buchan RJ; Mazankowski Alberta Heart Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta T6G 2R3, Canada.
  • Chowdhury RA; Systems Biology Imaging Platform, Berlin Institute for Medical Systems Biology (BIMSB), Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), 10115 Berlin, Germany.
  • Constantinou C; Digital Health-Machine Learning group, Hasso Plattner Institute for Digital Engineering, University of Potsdam, 14482 Potsdam, Germany.
  • Cranley J; Hasso Plattner Institute for Digital Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Felkin LE; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
  • Fox H; Cardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Ghauri A; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany.
  • Gummert J; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
  • Kanda M; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.
  • Li R; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
  • Mach L; Cardiac Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
  • McDonough B; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.
  • Samari S; Royal Brompton and Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London SW3 6NR, UK.
  • Shahriaran F; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.
  • Yapp C; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.
  • Stanasiuk C; Cellular Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.
  • Theotokis PI; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.
  • Theis FJ; Royal Brompton and Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London SW3 6NR, UK.
  • van den Bogaerdt A; Heart and Diabetes Center NRW, Clinic for Thoracic and Cardiovascular Surgery, University Hospital of the Ruhr-University, 32545 Bad Oeynhausen, Germany.
  • Wakimoto H; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany.
  • Ware JS; Heart and Diabetes Center NRW, Clinic for Thoracic and Cardiovascular Surgery, University Hospital of the Ruhr-University, 32545 Bad Oeynhausen, Germany.
  • Worth CL; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany.
  • Barton PJR; Department of Rheumatology and Clinical Immunology, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan.
  • Lee YA; Cellular Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.
  • Teichmann SA; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.
  • Milting H; Royal Brompton and Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London SW3 6NR, UK.
  • Noseda M; Cardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Oudit GY; Howard Hughes Medical Institute, Bethesda, MD 20815, USA.
Science ; 377(6606): eabo1984, 2022 08 05.
Article in En | MEDLINE | ID: mdl-35926050
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Full text: 1 Database: MEDLINE Main subject: Cardiomyopathy, Dilated / Arrhythmogenic Right Ventricular Dysplasia / Single-Cell Analysis / Transcriptome / Heart Failure Limits: Humans Language: En Year: 2022 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Cardiomyopathy, Dilated / Arrhythmogenic Right Ventricular Dysplasia / Single-Cell Analysis / Transcriptome / Heart Failure Limits: Humans Language: En Year: 2022 Type: Article