[Health economic evaluation of four prenatal screening strategies for Down syndrome in Changsha, China].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
; 39(8): 803-808, 2022 Aug 10.
Article
in Zh
| MEDLINE
| ID: mdl-35929926
ABSTRACT
OBJECTIVE:
To compare the clinical application and health economic values of non-invasive prenatal testing (NIPT) and second trimester serum screening (STSS).METHODS:
A retrospective analysis was carried out on 54 026 singleton pregnant women undergoing NIPT and STSS from March 1, 2018 to December 31, 2019 in Changsha Maternal and Child Health Care Hospital. For pregnant women with high-risk results of NIPT, prenatal diagnosis and follow-up of pregnancy outcomes were conducted. The data was grouped to 4 screening models, and their cost-benefit was analyzed.RESULTS:
The sensitivity, specificity and positive predictive value of NIPT were all higher than STSS. Screening models 1 to 4 have prevented the birth of 71, 29, 52 and 54 patients with Down syndrome, respectively. The safety index of screening models 1 to 4 were 0.0036, 0.3944, 02215 and 0.1281, respectively. When the price of NIPT was decreased to 600 RMB, the cost-benefit of the screening models 1 to 4 was 0.46, 0.65, 0.44 and 0.40 million RMB, respectively.CONCLUSION:
NIPT has a better detection performance than STSS. When the price of NIPT is 600 RMB, screening model 1 has the best screening effect and the highest accuracy, safety index and health economical value.
Full text:
1
Database:
MEDLINE
Main subject:
Down Syndrome
Type of study:
Diagnostic_studies
/
Health_economic_evaluation
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limits:
Child
/
Female
/
Humans
/
Pregnancy
Country/Region as subject:
Asia
Language:
Zh
Year:
2022
Type:
Article