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Multicompartmental Microcapsules for Enzymatic Cascade Reactions Prepared through Gas Shearing and Surface Gelation.
Qu, Qingli; Cheng, Weixia; Zhang, Xiaoli; Zhou, Aying; Deng, Yankang; Zhu, Miaomiao; Chu, Tianjiao; Manshian, Bella B; Xiong, Ranhua; Soenen, Stefaan J; Braeckmans, Kevin; De Smedt, Stefaan C; Huang, Chaobo.
Affiliation
  • Qu Q; Joint Laboratory of Advanced Biomedical Materials (NFU-UGent), Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University (NFU), Nanjing 210037, P. R. China.
  • Cheng W; Children's Hospital of Nanjing Medical University, Nanjing 210008, P. R. China.
  • Zhang X; Joint Laboratory of Advanced Biomedical Materials (NFU-UGent), Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University (NFU), Nanjing 210037, P. R. China.
  • Zhou A; Joint Laboratory of Advanced Biomedical Materials (NFU-UGent), Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University (NFU), Nanjing 210037, P. R. China.
  • Deng Y; Joint Laboratory of Advanced Biomedical Materials (NFU-UGent), Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University (NFU), Nanjing 210037, P. R. China.
  • Zhu M; Joint Laboratory of Advanced Biomedical Materials (NFU-UGent), Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University (NFU), Nanjing 210037, P. R. China.
  • Chu T; NanoHealth and Optical Imaging Group, Department of Imaging and Pathology, KULeuven, Herestraat 49, B3000 Leuven, Belgium.
  • Manshian BB; Translation Cell and Tissue Research Unit, Department of Imaging and Pathology, KULeuven, Herestraat 49, B3000 Leuven, Belgium.
  • Xiong R; Leuven Cancer Institute, KULeuven, Herestraat 49, B3000 Leuven, Belgium.
  • Soenen SJ; Joint Laboratory of Advanced Biomedical Materials (NFU-UGent), Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University (NFU), Nanjing 210037, P. R. China.
  • Braeckmans K; NanoHealth and Optical Imaging Group, Department of Imaging and Pathology, KULeuven, Herestraat 49, B3000 Leuven, Belgium.
  • De Smedt SC; Leuven Cancer Institute, KULeuven, Herestraat 49, B3000 Leuven, Belgium.
  • Huang C; Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, 9000 Ghent, Belgium.
Biomacromolecules ; 23(9): 3572-3581, 2022 09 12.
Article in En | MEDLINE | ID: mdl-35931466
Inspired by the structure of eukaryotic cells, multicompartmental microcapsules have gained increasing attention. However, challenges remain in the fabrication of "all-aqueous" (i.e., oil-free) microcapsules composed of accurately adjustable hierarchical compartments. This study reports on multicompartmental microcapsules with an innovative architecture. While multicompartmental cores of the microcapsules were fabricated through gas shearing, a shell was applied on the cores through surface gelation of alginate. Different from traditional multicompartmental microcapsules, thus obtained microcapsules have well-segregated compartments while the universal nature of the surface-gelation method allows us to finely tune the shell thicknesses of the microcapsules. The microcapsules are highly stable and cytocompatible and allow repeated enzymatic cascade reactions, which might make them of interest for complex biocatalysis or for mimicking physiological processes.
Subject(s)

Full text: 1 Database: MEDLINE Main subject: Water / Alginates Language: En Year: 2022 Type: Article

Full text: 1 Database: MEDLINE Main subject: Water / Alginates Language: En Year: 2022 Type: Article