Clinical course and serum amyloid ß levels in elderly patients with major depressive disorder.
J Affect Disord
; 315: 156-161, 2022 10 15.
Article
in En
| MEDLINE
| ID: mdl-35932935
ABSTRACT
BACKGROUND:
Depression is known to be a risk factor for Alzheimer's disease (AD). Changes in amyloid ß protein (Aß) metabolism have been speculated as a factor contributing to the transition from depression to AD. The aim of this study is to reveal the time course and state-dependency of Aß metabolism.METHODS:
Serum Aß levels in 277 elderly (≥60 years) patients with depression (both early- and late-onset) were measured at admission, immediately after remission, and 1 year after remission, and compared them with 178 healthy subjects.RESULTS:
The analysis revealed decreased Aß42 levels and increased Aß42/40 ratios in elderly patients with depression at admission compared with healthy subjects. These changes in the acute phase of depression were not normalized immediately after remission; however, they recovered to healthy levels 1 year after remission.LIMITATIONS:
There is a possibility that the results may be influenced by antidepressants.CONCLUSIONS:
These results suggest that altered Aß metabolism caused by depression may ameliorate, although after a lengthy period of time after remission. Our findings also suggest that the AD-related pathological changes caused or increased by depression can be reduced by maintaining remission for an extended period of time.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Depressive Disorder, Major
/
Alzheimer Disease
Type of study:
Risk_factors_studies
Limits:
Aged
/
Humans
Language:
En
Year:
2022
Type:
Article